{"id":17,"date":"2016-03-07T15:20:39","date_gmt":"2016-03-07T14:20:39","guid":{"rendered":"https:\/\/filozofia.nett.to\/psychedelika\/2016\/03\/07\/konope-cannabis-z-vedeckeho-pohladu\/"},"modified":"2026-01-30T18:11:06","modified_gmt":"2026-01-30T17:11:06","slug":"konope-cannabis-z-vedeckeho-pohladu","status":"publish","type":"post","link":"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/","title":{"rendered":"Konope, Cannabis, z vedeck\u00e9ho poh\u013eadu"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Pravne_postavenie\" >Pr\u00e1vne postavenie<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Kumulativnost\" >Kumulat\u00edvnos\u0165<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Hospitalizacia_na_psychiatrickom_oddeleni\" >Hospitaliz\u00e1cia na psychiatrickom oddelen\u00ed<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Bezpecnostne_pokyny\" >Bezpe\u010dnostn\u00e9 pokyny<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Lumir_Hanus\" >Lumir Hanu\u0161<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#THC_a_CBD\" >THC a CBD<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Kanabinoidne_receptory_vseobecne\" >Kanabinoidn\u00e9 receptory v\u0161eobecne<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Lekarske_vyuzitie\" >Lek\u00e1rske vyu\u017eitie:<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Chut_do_jedla\" >Chu\u0165 do jedla<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Rakovina\" >Rakovina<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Diabetes\" >Diabetes<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Anandamid\" >Anandamid<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Kanabinoidny_receptor_1_CB1\" >Kanabinoidn\u00fd receptor 1, (CB1)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#CBD_%E2%80%93_Cannabidiol\" >CBD &#8211; Cannabidiol<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#THC_%E2%80%93_Tetrahydrocannabinol\" >THC &#8211; Tetrahydrocannabinol<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#CBG_%E2%80%93_Cannabigerol_a_alfa2_receptor\" >CBG &#8211; Cannabigerol a alfa2 receptor<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Inhibitor_acetylcholinesterazy\" >Inhib\u00edtor acetylchol\u00ednester\u00e1zy<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Inhibitor_acetylcholinesterazy_parasympatimymetikum_Anticholinesteraza\" >Inhib\u00edtor acetylchol\u00ednester\u00e1zy, parasympatimymetikum, Antichol\u00ednester\u00e1za<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Muskarin\" >Muskar\u00edn<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/filozofia.nett.to\/psychedelika\/sk\/konope-cannabis-z-vedeckeho-pohladu\/#Kombinacia_konope_a_alkoholu\" >Kombin\u00e1cia konope a alkoholu<\/a><\/li><\/ul><\/nav><\/div>\n<p><h2><span class=\"ez-toc-section\" id=\"Pravne_postavenie\"><\/span><strong>Pr\u00e1vne postavenie<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n\u010cesko patr\u00ed medzi krajiny s liber\u00e1lnej\u0161\u00edmi z\u00e1konmi o drog\u00e1ch. THC sa nach\u00e1dza spolu s najzn\u00e1mej\u0161\u00edmi psychedelikami v rovnakej skupine. Za men\u0161ie mno\u017estvo dr\u017eania marihuany v \u010cesku je len priestupok-pokuta.<br \/><br \/>Na Slovensku jednotlivec m\u00f4\u017ee pestova\u0165 konope s n\u00edzkym obsahom THC aj bez povolenia. Po ur\u010ditom \u010dase zrejme u\u017e u ka\u017ed\u00e9ho druhu konope je vy\u0161\u0161\u00ed obsah THC a teda odvtedy to u\u017e prest\u00e1va by\u0165 leg\u00e1lne.\r\nPod\u013ea z\u00e1kona vydan\u00e9ho EU, ktor\u00fd plat\u00ed aj na Slovensku, maj\u00fa farm\u00e1ri, pokia\u013e viem aj viac menej bez povolenia (asi sta\u010d\u00ed len nejak\u00e9 ozn\u00e1menie), dovolen\u00e9 pestova\u0165 technick\u00e9 konope (z n\u00edzkym obsahom THC) aj do \u00faplneho dozretia. Farm\u00e1ri maj\u00fa povinnos\u0165 a str\u00e1\u017ei\u0165 konopn\u00e9 polia (aby sa tam nikto nedostal) v \u010dasoch ke\u010f u\u017e konope m\u00e1 vy\u0161\u0161\u00ed obsah THC.\r\nV SR je mo\u017en\u00e9 pestova\u0165 konope s vysok\u00fdm obsahom THC za podmienky, ak si \u010dlovek vybav\u00ed povolenie na Ministerstve zdravotn\u00edctva.<br \/><br \/>V \u010cesku sa nach\u00e1dza siln\u00e9 hnutie za podporu \u00faplnej legaliz\u00e1cie konope. V \u010ceskom jazyku sa vyd\u00e1va aj \u010dasopis o konope.<br \/><br \/>Najviac sa vedeck\u00fdm v\u00fdskumom konope zaober\u00e1 univerzita v Izraeli.<br \/><br \/>V niektor\u00fdch \u0161t\u00e1toch je konope aj \u00faplne ofici\u00e1lne dovolen\u00e1 na lie\u010dbu, lek\u00e1ri ju m\u00f4\u017eu predpisova\u0165 a miestne lek\u00e1rsko &#8211; farmakologick\u00e9 \u00farady vyp\u00edsali aj konkr\u00e9tne indik\u00e1cie. Ide o \u0161t\u00e1ty Holandsko, Belgicko, Izrael a niektor\u00e9 \u0161t\u00e1ty USA.<br \/><br \/>Z vedeck\u00e9ho uh\u013ea poh\u013eadu to s konope<strong> nie je \u010dierne ani biele<\/strong>.<strong> D\u00e9monizovanie a ospevovanie konope s\u00fa dve extr\u00e9my mimo reality.<\/strong>\r\nRadik\u00e1lni z\u00e1stancovia konope hovoria, \u017ee konope je absol\u00fatny v\u0161eliek na v\u0161etky choroby. To samozrejme nie je pravda, ale na druhej strane je treba uzna\u0165, \u017ee konope je najv\u00fdznamnej\u0161ou a najviac ve\u013ekolepou lie\u010divou rastlinou ak\u00e1 len existuje. M\u00e1 nesmierne \u0161irok\u00e9 lie\u010debn\u00e9 vyu\u017eitie.<strong> Konope je jednozna\u010dn\u00fdm rekord\u00e9rom medzi lie\u010div\u00fdmi rastlinami.<\/strong>\r\nNa druhej strane m\u00f4\u017ee konope spusti\u0165 niektor\u00e9 choroby alebo sp\u00f4sobi\u0165 utrpenie.\r\nKonope bude asi rekord\u00e9rom s pomedzi v\u0161etk\u00fdch psychoakt\u00edvnych l\u00e1tok, vo vyvol\u00e1van\u00ed du\u0161evn\u00fdch por\u00fach (alebo ich pr\u00edznakov) ako s\u00fa<strong> depresia a psych\u00f3za<\/strong> (schizofr\u00e9nia). Pri rekrea\u010dnom pou\u017e\u00edvan\u00ed je \u010dast\u00e1 aj<strong> paranoja a z\u00e1chvaty paniky, disoci\u00e1cia, depersonaliz\u00e1cia a derealiz\u00e1cia.<\/strong>\r\nTreba pripomen\u00fa\u0165, \u017ee konope sama o sebe nesp\u00f4sobuje schizofr\u00e9niu, probl\u00e9m je len u t\u00fdch \u013eud\u00ed, ktor\u00ed maj\u00fa k tomu predispoz\u00edciu.<br \/><br \/>Psychedelick\u00e9 l\u00e1tky s\u00fa neporovnate\u013ene viac bezpe\u010dn\u00e9 ako marihuana, \u010do do rizika psychick\u00fdch por\u00fach. Marihuana je GABA antagonista a 5-HT (to jest seroton\u00ednov\u00fd) antagonista, \u010do znamen\u00e1 silne depresie vyvol\u00e1vaj\u00faca l\u00e1tka. Depres\u00edvne z\u00e1\u017eitky pri konope s\u00fa naj\u010dastej\u0161ie s pomedzi v\u0161etk\u00fdch psychoakt\u00edvnych l\u00e1tok, hoci niekedy m\u00f4\u017eu by\u0165 aj pozit\u00edvne z\u00e1\u017eitky. Konope m\u00f4\u017ee by\u0165 \u010dasto aj sp\u00fa\u0161\u0165a\u010d schizofr\u00e9nie &#8211; aj kv\u00f4li tomu, \u017ee THC je aj NMDA antagonista (m\u00f4\u017ee to tam zohr\u00e1va\u0165 ur\u010dit\u00fa \u00falohu). Psychedelick\u00e9 l\u00e1tky sa s marihuanou \u010do do rizika psychick\u00fdch por\u00fach nedaj\u00fa porovn\u00e1va\u0165, tam je podstatne ni\u017e\u0161ie riziko.\r\n<h2><span class=\"ez-toc-section\" id=\"Kumulativnost\"><\/span><strong>Kumulat\u00edvnos\u0165<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\nTHC m\u00e1 zvl\u00e1\u0161tnu vlastnos\u0165, \u017ee sa via\u017ee v tele dos\u0165 dlho a dok\u00e1\u017ee sa ur\u010dit\u00fdm sp\u00f4sobom akumulova\u0165. Je to zrejme sp\u00f4soben\u00e9 ve\u013emi n\u00edzkou chemickou rozpustnos\u0165ou THC vo vode, teda len tak r\u00fdchlo sa z tela nevyplav\u00ed. Tie\u017e r\u00f4zne drogov\u00e9 detektory dok\u00e1\u017eu zisti\u0165 u\u017eitie konope, neviem \u010di a\u017e nieko\u013eko mesiacov po poslednom u\u017eit\u00ed.\r\nNapr. ist\u00fd \u010dlovek popisuje \u00fa\u010dinok konope tak, \u017ee ke\u010f prv\u00fd de\u0148 dal konope prekvapivo sa ni\u010d nedialo. Na druh\u00fd de\u0148 si dal \u010fal\u0161iu d\u00e1vku konope a za\u017eil z toho poriadny randal\r\n<h2><span class=\"ez-toc-section\" id=\"Hospitalizacia_na_psychiatrickom_oddeleni\"><\/span><strong>Hospitaliz\u00e1cia na psychiatrickom oddelen\u00ed<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\nTHC p\u00f4sob\u00ed ve\u013emi dlho. Po\u010dul som o starom \u010dloveku, ktor\u00fd za\u017eil intoxika\u010dn\u00fa psych\u00f3zu aj cel\u00e9 2-3 dni a potom sa to vr\u00e1tilo do norm\u00e1lu (chceli mu da\u0165 konope pre lie\u010debn\u00fd \u00fa\u010del).\r\nPreto z diagnostikovan\u00edm psych\u00f3zy, je treba by\u0165 ve\u013emi opatrn\u00fd, aby pacient neu\u017e\u00edval psychiatrick\u00e9 lieky zbytok \u017eivota \u00faplne zbyto\u010dne. Treba trpezlivo vy\u010dk\u00e1va\u0165 najmenej 5 dn\u00ed, \u010di psych\u00f3za nezmizne sama.\r\nNako\u013eko je THC antagonista na GABA a seroton\u00ednov\u00e9 receptory, v r\u00e1mci hospitaliz\u00e1cie bude rozumn\u00e9 pod\u00e1va\u0165 pacientovi prekurzor seroton\u00ednu<strong> tryptof\u00e1n<\/strong> a<strong> kyselinu valproov\u00fa<\/strong> (ktor\u00fa pr\u00edpadne m\u00f4\u017ee s rovnak\u00fdmi \u00fa\u010dinkami nahradi\u0165 aj \u013eubovo\u013en\u00e9 sedat\u00edvum\/benzodiazep\u00edn).\r\nVedeck\u00e9 \u0161t\u00fadie uk\u00e1zali, \u017ee opioidn\u00e9 blok\u00e1tory zni\u017euj\u00fa \u00fa\u010dinky THC. Pacientovi sa teda v r\u00e1mci hospitaliz\u00e1cie m\u00e1 poda\u0165<strong> nalox\u00f3n<\/strong> alebo<strong> naloxonaz\u00edn.<\/strong> <a href=\"https:\/\/en.wikipedia.org\/wiki\/Tetrahydrocannabinol#Interactions\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Tetrahydrocannabinol#Interactions<\/a>\r\nTak\u017ee v nemocnici by mal pacient prija\u0165 dokopy 3 druhy liekov.\r\n<h2><span class=\"ez-toc-section\" id=\"Bezpecnostne_pokyny\"><\/span><strong>Bezpe\u010dnostn\u00e9 pokyny<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\nNajviac rizikov\u00e9 je to s t\u00fdm \u010dlovekom, ktor\u00fd u\u017e\u00edva d\u00e1vku konope prv\u00fd kr\u00e1t. Po spr\u00e1vnosti mal by ma\u0165 zo za\u010diatku ve\u013emi opatrn\u00fa d\u00e1vku a d\u00e1vky postupne opatrne zvy\u0161ova\u0165. Tak radia \u013eudia, ktor\u00ed sa zaoberaj\u00fa lie\u010dbou konope. Ak si CNS na THC zvykne, potom to u\u017e za\u010d\u00edna by\u0165 v celku bezpe\u010dn\u00e9.\r\nKonope nepatr\u00ed medzi silne n\u00e1vykov\u00e9 l\u00e1tky, ale na t\u00fdch ktor\u00ed sa stali z\u00e1visl\u00ed a m\u00e1vaj\u00fa denne vysok\u00e9 d\u00e1vky konope, je mo\u017en\u00e9 pozorova\u0165 ur\u010dit\u00e9 naru\u0161enie kognit\u00edvnych schopnost\u00ed. Nako\u013eko m\u00e1 THC kumulat\u00edvne vlastnosti, z\u00e1visl\u00fd je pod vplyvom THC 24 hod\u00edn denne bez prest\u00e1vky. (Ale po\u010das faj\u010denia s\u00fa \u00fa\u010dinky samozrejme obzvl\u00e1\u0161\u0165 intenz\u00edvne).\r\n<h2><span class=\"ez-toc-section\" id=\"Lumir_Hanus\"><\/span><strong>Lumir Hanu\u0161<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\nAsi najv\u00fdraznej\u0161ou osobnos\u0165ou \u010do do vedeck\u00e9ho v\u00fdskumu konope je \u010desk\u00fd chemik Lumir Hanu\u0161 p\u00f4sobiaci moment\u00e1lne v Izraeli.\r\nKonope, okrem toho \u017ee je seroton\u00ednov\u00fd a GABA antagonista (presnej\u0161ie povedan\u00e9 antagonista a seroton\u00ednov\u00e9 a GABA receptory), p\u00f4sob\u00ed tie\u017e na kanabioidn\u00e9 receptory. U\u017e d\u00e1vno sa vedelo, \u017ee kanabioidn\u00e9 rceptory existuj\u00fa, ale Lumir Hanu\u0161 urobil prielomov\u00fd objav v tom, \u017ee objavil neurotransmitern\u00fa l\u00e1tku<strong> anandamid<\/strong>, ktor\u00e1 je viazan\u00e1 na tieto receptory.\r\nV tejto telev\u00edznej rel\u00e1cii podrobne popisuje, ako t\u00fato l\u00e1tku objavil, ako zistili, \u017ee ak\u00fa molekul\u00e1rnu \u0161trukt\u00fara m\u00e1 t\u00e1to nov\u00e1 nezn\u00e1ma l\u00e1tka\r\n<a href=\"https:\/\/en.wikipedia.org\/wiki\/Lum%C3%ADr_Ond%C5%99ej_Hanu%C5%A1\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Lum%C3%ADr_Ond%C5%99ej_Hanu%C5%A1<\/a>\r\n<a href=\"http:\/\/www.ceskatelevize.cz\/porady\/1093836883-na-plovarne\/212522160100025-na-plovarne-s-lumirem-hanusem\/\" target=\"_blank\" rel=\"noopener\">http:\/\/www.ceskatelevize.cz\/porady\/1093836883-na-plovarne\/212522160100025-na-plovarne-s-<\/a><a href=\"http:\/\/www.ceskatelevize.cz\/porady\/1093836883-na-plovarne\/212522160100025-na-plovarne-s-lumirem-hanusem\/\" target=\"_blank\" rel=\"noopener\">lumirem-hanusem\/<\/a>\r\nNa ka\u017ed\u00fd druh receptorov sa via\u017ee nejak\u00e1 neurotransmitern\u00e1 l\u00e1tka (neurotransmiter). Pokia\u013e sa nem\u00fdlim, tak neurotransmiteru sa hovor\u00ed aj endog\u00e9nny ligand.\r\nNajzn\u00e1mej\u0161ie neurotransmitery s\u00fa seroton\u00edn, dopam\u00edn, noradrenal\u00edn, acetylchol\u00edn, NMDA, GABA.\r\nNa opioidn\u00e9 receptory s\u00fa v\u00fdnimo\u010dn\u00e9 t\u00fdm, \u017ee sa na ne nevia\u017ee len jedna l\u00e1tka ale asi 3 l\u00e1tky.\r\n<h2><span class=\"ez-toc-section\" id=\"THC_a_CBD\"><\/span><strong>THC a CBD<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\nNajv\u00fdznamnej\u0161ie a najzn\u00e1mej\u0161ie \u00fa\u010dinn\u00e9 l\u00e1tky konope s\u00fa THC a CBD. CBD nie je psychoakt\u00edvna l\u00e1tka.\r\nExistuj\u00fa r\u00f4zne druhy konope, ktor\u00e9 maj\u00fa oboje l\u00e1tky zast\u00fapen\u00e9 vo r\u00f4znych pomeroch.\r\n<strong>CBD blokuje psychoakt\u00edvne vlastnosti THC<\/strong>. \u013dudia, ktor\u00ed pou\u017e\u00edvaj\u00fa konope na lie\u010debn\u00e9 \u00fa\u010dely vyh\u013ead\u00e1vaj\u00fa druhy, ktor\u00e9 maj\u00fa pribli\u017ene rovnak\u00fd pomer THC a CBD. Tomuto druhu konope sa neprejavia psychoakt\u00edvne vlastnosti THC.\r\nNaopak \u013eudia, ktor\u00ed vyh\u013ead\u00e1vaj\u00fa konope pre rekrea\u010dn\u00e9 \u00fa\u010dely, chc\u00fa ma\u0165 v danom druhu konope \u010do najviac THC a \u010do najmenej CBD.\r\nSyntetick\u00e9 THC je najviac nebezpe\u010dn\u00e9, \u010do do vyvol\u00e1vania psych\u00f3zy, preto\u017ee je bez CBD. Syntetick\u00e9 kanabinoidy sa sp\u00e1jaj\u00fa aj s pr\u00edznakmi epilepsie a srdcov\u00fdm infarktom, preto\u017ee srdcov\u00fd tlak dos\u0165 kol\u00ed\u0161e, paranoja tie\u017e srdcov\u00fd tlak zv\u00fd\u0161i <a href=\"https:\/\/en.wikipedia.org\/wiki\/Synthetic_cannabis\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Synthetic_cannabis<\/a><br \/><br \/>-konope sa m\u00f4\u017ee<strong> faj\u010di\u0165 cez bongo alebo vaporiz\u00e9r<\/strong>. Vaporiz\u00e9r premie\u0148a \u00fa\u010dinn\u00e9 l\u00e1tky na plynn\u00e9 skupenstvo bez pr\u00edstupu vzduchu. \u010clovek takto neinhaluje \u017eiadne \u0161kodliv\u00e9 dechty ani \u0161kodliv\u00e9 chemick\u00e9 l\u00e1tky, ktor\u00e9 by vznikli pri be\u017enom spa\u013eovan\u00ed z fajky a podobne\r\n<a href=\"https:\/\/en.wikipedia.org\/wiki\/Bong\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Bong<\/a>\r\n<a href=\"https:\/\/cs.wikipedia.org\/wiki\/Bong\" target=\"_blank\" rel=\"noopener\">https:\/\/cs.wikipedia.org\/wiki\/Bong<\/a>\r\n<a href=\"https:\/\/en.wikipedia.org\/wiki\/Vaporizer_(inhalation_device)\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Vaporizer_(inhalation_device)<\/a>\r\n<a href=\"https:\/\/cs.wikipedia.org\/wiki\/Vaporiz%C3%A9r\" target=\"_blank\" rel=\"noopener\">https:\/\/cs.wikipedia.org\/wiki\/Vaporiz%C3%A9r<\/a>\r\n-konope m\u00f4\u017ee by\u0165 pou\u017eit\u00e1 aj ako enteog\u00e9n, av\u0161ak aj s patri\u010dn\u00fdm rizikom\r\n&#8211;<strong>potenci\u00e1l z\u00e1vislosti<\/strong> je 9% z celkov\u00fdch experiment\u00e1torov z konope a pri dennom u\u017e\u00edvan\u00ed je potenci\u00e1l z\u00e1vislosti 10-20%\r\n-konope m\u00e1 n\u00edzku toxicitu a zatia\u013e nie je dok\u00e1zan\u00e9, \u017ee by nejak\u00fd \u010dlovek umrel kv\u00f4li pred\u00e1vkovaniu\r\n-pr\u00e1vnick\u00e9 zmeny v USA<em> &#8220;Odstr\u00e1nenie konope zo Zoznamu I z\u00e1kona o kontrolovan\u00fdch l\u00e1tok&#8221;<\/em> <a href=\"https:\/\/en.wikipedia.org\/wiki\/Cannabis_rescheduling_in_the_United_States\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Cannabis_rescheduling_in_the_United_States<\/a>\r\n<h2><span class=\"ez-toc-section\" id=\"Kanabinoidne_receptory_vseobecne\"><\/span><strong>Kanabinoidn\u00e9 receptory v\u0161eobecne<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n-kanabinoidn\u00e9 receptory (CB1 a CB2) sa nach\u00e1dzaj\u00fa v perif\u00e9rnom tkanive mozgu a CB2 hlavne v gliov\u00fdch bunk\u00e1ch\r\n-v hypocampe kanabinoidy zni\u017euj\u00fa uvo\u013enovane acetylchol\u00ednu, noradrenal\u00ednu a glutam\u00e1tu (ktor\u00fd s\u00favis\u00ed s NMDA receptormi)\r\n-CBD je 5-HT1A agonista, to znamen\u00e1, \u017ee v tomto p\u00f4sob\u00ed protichodne k THC\r\n&#8211;<strong>v materskom mlieku<\/strong> sa nach\u00e1dzaj\u00fa l\u00e1tky, ktor\u00e9 zvy\u0161uj\u00fa aktivitu kanabinoidn\u00fdm receptorom. Matersk\u00e9 mlieko teda zohr\u00e1va d\u00f4le\u017eit\u00fa \u00falohu v imunite. Kanabioidn\u00e9 l\u00e1tky v materskom mlieku zv\u00fd\u0161ia chu\u0165 do jedla, \u010do sp\u00f4sob\u00ed die\u0165a\u0165u v\u00e4\u010d\u0161iu motiv\u00e1ciu a chu\u0165 pi\u0165 mlieko z prsn\u00edkov matky. Ide o l\u00e1tky napr.<strong> 2-Arachidonoylglycerol<\/strong>\r\n<h2><span class=\"ez-toc-section\" id=\"Lekarske_vyuzitie\"><\/span><strong>Lek\u00e1rske vyu\u017eitie:<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n<h3><span class=\"ez-toc-section\" id=\"Chut_do_jedla\"><\/span><strong>Chu\u0165 do jedla<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\r\n-nako\u013eko je konope antagonista na seroton\u00ednov\u00e9 receptory, zvy\u0161uje chu\u0165 do jedla a v pr\u00edpade chemoterapie zabr\u00e1ni zvracaniu. To m\u00e1 ale ve\u013ek\u00fa nev\u00fdhodu v<strong> prejedan\u00ed a obezite.<\/strong> Vedci sa pok\u00fasili vysvetli\u0165, \u017ee za chu\u0165 do jedla zodpovedaj\u00fa okrem seroton\u00ednov\u00fdch aj kanabinoidn\u00e9 receptory. \u010ci je ich hypot\u00e9za pravdiv\u00e1, je \u0165a\u017eko poveda\u0165, preto\u017ee je zn\u00e1me, \u017ee za chu\u0165 do jedla zodpovedaj\u00fa hlavne seroton\u00ednov\u00e9 receptory.\r\nKonope je vhodn\u00e1<strong> proti zvracaniu<\/strong> kv\u00f4li chemoterapii,\r\nje vhodn\u00e1 na pre \u013eud\u00ed s AIDS a rakovinou, aby mali chu\u0165 do jedla (nechu\u0165 do jedla je u t\u00fdchto \u013eud\u00ed ve\u013emi v\u00e1\u017eny probl\u00e9m).\r\nExistuj\u00fa aj syntetick\u00e9 (nie prirodzen\u00e9) l\u00e1tky ktor\u00e9 s\u00fa antagonisti na kanabinoidn\u00e9 receptory. Cie\u013eom vedcov bolo tak zhotovi\u0165 liek, ktor\u00fd potl\u00e1\u010da chu\u0165 do jedla, liek na chudnutie. Zrejme sa u\u017e tieto lieky v klinickej praxi aj pou\u017e\u00edvaj\u00fa.\r\n-konope s vysok\u00fdm obsahom CBD a n\u00edzkym obsahom THC je dobr\u00e1 na lie\u010dbu epilepsie\r\n-konope je<strong> hypotenz\u00edvum<\/strong> v r\u00e1mci dlhodob\u00e9ho nie rekrea\u010dn\u00e9ho pou\u017e\u00edvania. Oplat\u00ed sa ho zrejme pou\u017e\u00edva\u0165 na hypertenziu samotn\u00fa. Nie je vhodn\u00e1 pre \u013eud\u00ed z n\u00edzkym krvn\u00fdm tlakom.\r\nKonope tie\u017e roz\u0161iruje cievy, \u010do zni\u017euje krvn\u00fd tlak.\r\nCB1 receptory sa \u00fadajne nach\u00e1dzaj\u00fa aj v dreni nadobli\u010diek ktor\u00e9 vylu\u010duj\u00fa<strong> adrenal\u00edn<\/strong>, to znamen\u00e1, \u017ee aj to m\u00f4\u017ee zohr\u00e1va\u0165 d\u00f4le\u017eit\u00fa \u00falohu na \u010dinnos\u0165 srdca a krvn\u00fd tlak.\r\nAv\u0161ak pri n\u00e1razov\u00fdch rekrea\u010dn\u00fdch d\u00e1vkach a rekrea\u010dnom u\u017e\u00edvan\u00ed (s vysok\u00fdm obsahom THC a n\u00edzkym CBD), doch\u00e1dza naj\u010dastej\u0161ie k zv\u00fd\u0161eniu krvn\u00e9ho tlaku (mo\u017eno aj z d\u00f4vodu siln\u00e9ho vzru\u0161iv\u00e9ho z\u00e1\u017eitku \u010di paranoje). Pri rekrea\u010dnom pou\u017e\u00edvan\u00ed m\u00f4\u017ee krvn\u00fd tlak kol\u00edsa\u0165 a meni\u0165 sa srdcov\u00e1 frekvencia. Toto kol\u00edsanie krvn\u00e9ho tlaku mo\u017eno vn\u00edma\u0165 ako potencion\u00e1lne rizikov\u00e9\r\n-obzvl\u00e1\u0161\u0165 \u00fa\u010dinne zni\u017euje vn\u00fatroo\u010dn\u00fd tlak, je vhodn\u00e1 na<strong> glauk\u00f3m<\/strong>\r\n&#8211;<strong>p\u013e\u00faca:<\/strong> pri faj\u010den\u00ed s\u00fa \u0161kodliv\u00e9 dechty. Existuje riziko p\u013eucnych ochoren\u00ed a pr\u00edpadne aj rakoviny p\u013e\u00fac. Dym je na p\u013e\u00faca \u0161kodlivej\u0161\u00ed ako dym tabaku. Rakovina p\u013e\u00fac nie je \u010dast\u00e1, preto\u017ee konope m\u00e1 protirakovinov\u00e9 \u00fa\u010dinky\r\n-Konope je vhodn\u00e1 na<strong> reumatoidn\u00fa artrit\u00eddu<\/strong>\r\n-konope m\u00e1 ve\u013emi dobr\u00e9<strong> analgetick\u00e9 \u00fa\u010dinky<\/strong>. U\u017e\u00edva\u0165 konope ako analgetikum je zrejme zdrav\u0161ie a omnoho \u00fa\u010dinnej\u0161ie, ako doteraz existuj\u00face farmaceutick\u00e9 v\u00fdrobky \/ lieky. Vhodn\u00e1 aj na<strong> migr\u00e9ny<\/strong> &#8211; na ne u\u017e v\u00f4bec nem\u00e1me \u00fa\u010dinn\u00e9 lieky\r\n-konope m\u00e1 obzvl\u00e1\u0161\u0165 siln\u00e9<strong> antioxida\u010dn\u00e9 \u00fa\u010dinky<\/strong> (teda zabra\u0148uje rakovine)\r\n-zabra\u0148uje rozvoju<strong> neurodegenerat\u00edvnych chor\u00f4b<\/strong> (neuroprotekcia)\r\n-CB2 receptory \u00fazko s\u00favisia<strong> s imunitou a \u010dinnos\u0165ou bielych krviniek<\/strong>. Faj\u010denie konope je rozhodne zdrav\u0161ie ako u\u017e\u00edvanie antibiot\u00edk. A antibiotik\u00e1 tak \u010di onak u mnoh\u00fdch \u013eud\u00ed nezaberaj\u00fa. Konope m\u00e1 ve\u013emi siln\u00fd<strong> protiz\u00e1palov\u00fd \u00fa\u010dinok<\/strong>.\r\nKonope dok\u00e1\u017ee ve\u013emi v\u00fdznamne pred\u013a\u017ei\u0165 \u017eivot u \u013eud\u00ed<strong> s AIDS<\/strong> a \u010diasto\u010dne potla\u010di\u0165 pr\u00edznaky tejto choroby\r\n-CB2 receptory sa nach\u00e1dzaj\u00fa aj okolo lymfatick\u00fdch ciev a preto ve\u013emi v\u00fdznamne ovplyv\u0148uj\u00fa imunitu\r\n-CB2 receptory s\u00favisia s nervov\u00fdmi imunitn\u00fdmi bunkami typu mikroglie. Konope je teda vhodn\u00e1 na lie\u010dbu infek\u010dn\u00fdch ochoren\u00ed, ktor\u00e9 nap\u00e1daj\u00fa CNS\r\n<h3><span class=\"ez-toc-section\" id=\"Rakovina\"><\/span><strong>Rakovina<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\r\n-Americk\u00e1 rakovinov\u00e1 spolo\u010dnos\u0165 ostro kritizovala z\u00e1kaz konope, preto\u017ee to prek\u00e1\u017ea vedeck\u00e9mu sk\u00famaniu p\u00f4sobenia konope na rakovinu\r\n-existuj\u00fa ur\u010dit\u00e9 v\u00fdskumy na zvierat\u00e1ch ktor\u00e9 dokazuj\u00fa, \u017ee konope dok\u00e1\u017ee ni\u010di\u0165 rakovinov\u00e9 bunky a posil\u0148ova\u0165 zdrav\u00e9\r\n-obzvl\u00e1\u0161\u0165 v\u00fdhodn\u00e9 sa zd\u00e1 by\u0165 pou\u017eite konope na lie\u010dbu<strong> rakoviny mozgu a prsn\u00edka<\/strong>\r\n-konope je vhodn\u00e1 na:<br \/><br \/>-kritici hovoria, \u017ee na mnoh\u00e9 choroby ktor\u00e9 je konope indikovan\u00e1,<strong> neexistuje dostatok d\u00f4kazov na lie\u010dbu<\/strong>. M\u00e1 to v\u0161ak jeden h\u00e1\u010dik. Ani ve\u013ek\u00e1 \u010das\u0165 syntetick\u00fdch farmakologik\u00fdch liekov nemaj dostatok d\u00f4kazov na \u00fa\u010dinnos\u0165 lie\u010dby tej \u010di onej choroby a napriek tomu sa pou\u017e\u00edvaj\u00fa. Zoberme si napr. extr\u00e9mne kontroverzn\u00fa chemoterapiu po ktorej polovica pacientov umiera. Mnoh\u00fdm liekom ani doteraz nevieme na akom princ\u00edpe funguj\u00fa, napr. ako je mo\u017en\u00e9 \u017ee opioidn\u00e9 blok\u00e1tory zni\u017euj\u00fa chu\u0165 do alkoholu a napriek tomu s\u00fa indikovan\u00e9 na alkoholizmus v mnoho krajin\u00e1ch vr\u00e1tane Slovenska\r\n&#8212;<strong>roztr\u00fasen\u00fa skler\u00f3zu<\/strong> a jej podobn\u00fdm diagn\u00f3zam, motorick\u00e9 poruchy\r\n&#8212;<strong>Tourettov syndr\u00f3m \u010di parkinsonizmus<\/strong>\r\n&#8212;<strong>Alzheimerovu chorobu<\/strong> (bolo aj vedeck\u00fdmi v\u00fdskumami podrobnej\u0161ie vysvetlen\u00e9 pre\u010do konope dobre p\u00f4sob\u00ed na t\u00fato chorobu, celkovo je inhib\u00edtorom acetylchol\u00ednexter\u00e1zy a p\u00f4sob\u00ed na Amyloid beta <a href=\"https:\/\/en.wikipedia.org\/wiki\/Amyloid_beta\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Amyloid_beta<\/a>)\r\n<h3><span class=\"ez-toc-section\" id=\"Diabetes\"><\/span><strong>Diabetes<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\r\nKonope dok\u00e1\u017ee zlep\u0161i\u0165 cel\u00fa radu negat\u00edvnych pr\u00edznakov diabetes. Pacient s diabetom si potrebuje picha\u0165 men\u0161ie mno\u017estvo inzul\u00ednu, m\u00e1 ni\u017e\u0161ie hodnoty cukru, zabra\u0148uje neuropatii, bolesti, zni\u017euje krvn\u00fd tlak a mnoho \u010fal\u0161ieho <a href=\"http:\/\/www.healthline.com\/diabetesmine\/treating_diabet\" target=\"_blank\" rel=\"noopener\">http:\/\/www.healthline.com\/diabetesmine\/treating_diabet<\/a>\r\n*\r\n&#8211;<strong>konopn\u00e9 semen\u00e1<\/strong> obsahuj\u00fa len ve\u013emi m\u00e1lo THC.<strong> Konopn\u00fd olej<\/strong> sa vyr\u00e1ba lisovan\u00edm konopn\u00fdch semien. Aj konopn\u00e9 semen\u00e1 maj\u00fa svoje \u0161irok\u00e9 lie\u010debn\u00e9 vyu\u017eitie, napr. atopick\u00fd ex\u00e9m\r\n<strong>-Nabiximols<\/strong> (obchodn\u00fd n\u00e1zov<strong> Sativex)<\/strong> je \u0161pecifick\u00fd v\u00fd\u0165a\u017eok z <a href=\"https:\/\/en.wikipedia.org\/wiki\/Cannabis\" target=\"_blank\" rel=\"noopener\"><em>konop<\/em>e<\/a> schv\u00e1len\u00fd ako <a href=\"https:\/\/en.wikipedia.org\/wiki\/Botanical_drug\" target=\"_blank\" rel=\"noopener\">botanick\u00fd liek<\/a>. Obsahuje rovnak\u00fd pomer THC a CBD\r\n-so syntetick\u00fdch liekov je zauj\u00edmav\u00fd or\u00e1lny sprej<strong> nabiximols<\/strong>. \u00da\u010dinn\u00e9 l\u00e1tky THC je mo\u017en\u00e9 prij\u00edma\u0165 aj cez p\u013e\u00faca\r\n<h2><span class=\"ez-toc-section\" id=\"Anandamid\"><\/span><strong>Anandamid<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n-anandamid je neurotransmitern\u00e1 l\u00e1tka kanabinoidn\u00fdch receptorov\r\n-sp\u00f4sobuje motiv\u00e1ciu, pete\u0161enie, dobr\u00fa n\u00e1ladu\r\n-uk\u00e1zalo sa, \u017ee t\u00e1to l\u00e1tka zohr\u00e1va d\u00f4le\u017eit\u00e9 \u00falohu v probl\u00e9me neplodnosti a zahniezdenia oplodnen\u00e9ho vaj\u00ed\u010dka v maternici\r\n-mal\u00e9 mno\u017estvo anandamidu je aj v \u010dokol\u00e1de\r\n-anandamid zastavuje bujnenie pri rakovine prsn\u00edka\r\n<h2><span class=\"ez-toc-section\" id=\"Kanabinoidny_receptor_1_CB1\"><\/span><strong>Kanabinoidn\u00fd receptor 1, (CB1)<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\nTento receptor je zodpovedn\u00fd za inhib\u00edciu uvo\u013e\u0148ovania glutam\u00e1tu a GABA. To znamen\u00e1, \u017ee THC je antagonista na excita\u010dn\u00e9 NMDA receptory a tie\u017e je antagonista na inhibi\u010dn\u00e9 GABA receptory.\r\nZjednodu\u0161ene povedan\u00e9 CB1 zni\u017euje aktivitu NMDA a GABA receptorom.\r\nNMDA antagonizmus by mohol vysvetli\u0165 pr\u00edznaky schizofr\u00e9nie po po\u017eit\u00ed konope\r\nCB 1 je exprimovan\u00fd v hypof\u00fdze a \u0161t\u00edtnej \u017e\u013eaze.\r\n<a href=\"https:\/\/en.wikipedia.org\/wiki\/Cannabinoid_receptor_type_1\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Cannabinoid_receptor_type_1<\/a>\r\n<h2><span class=\"ez-toc-section\" id=\"CBD_%E2%80%93_Cannabidiol\"><\/span><strong>CBD &#8211; Cannabidiol<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n-je vhodn\u00fd na lie\u010dbu rakoviny prsn\u00edka\r\n-agonista na 5-HT1A receptor (THC je antagonista na seroton\u00ednov\u00e9 receptory, tak\u017ee aj toto je jeden z mechanizmov ako CBD blokuje \u00fa\u010dinok THC)\r\n-CBD ma ve\u013emi n\u00edzku afinitu na CB1 a CB2. Nie je antagonistom na CB1 a CB2 ale je siln\u00fd antagonista\/blok\u00e1tor na agonistov t\u00fdchto receptorov\r\n-m\u00e1 neuroprotekt\u00edvne (proti neuro-degenerat\u00edvnym chorob\u00e1m) a anti-ischemick\u00e9 (proti nedokrvenosti tkan\u00edv, emb\u00f3lie a tromb\u00f3ze) \u00fa\u010dinky\r\n-Kanabidiol je <a href=\"https:\/\/en.wikipedia.org\/wiki\/Allosteric_modulator\" target=\"_blank\" rel=\"noopener\">alosterick\u00fd modul\u00e1tor<\/a> na <a href=\"https:\/\/en.wikipedia.org\/wiki\/Mu-opioid_receptor\" target=\"_blank\" rel=\"noopener\">opioid_receptor typu \u03bc<\/a> a <a href=\"https:\/\/en.wikipedia.org\/wiki\/%CE%94-opioid_receptor\" target=\"_blank\" rel=\"noopener\">\u03b4-opioidn\u00e9 receptory<\/a> (zvy\u0161uje aktivitu opioidn\u00fdm receptorom \u010do istotne prispieva k analgetick\u00fdm \u00fa\u010dinkom ale aj ku zlep\u0161eniu n\u00e1lady)\r\n-p\u00f4sob\u00ed proti \u00fazkostiam, depresii, soci\u00e1lnej \u00fazkostnej poruche\r\n-k\u00fdm THC psych\u00f3zu vyvol\u00e1va, naopak, CBD je ve\u013emi dobr\u00e9<strong> antipsychotikum<\/strong>. Je to zdanlivo paradoxn\u00e9, \u017ee jedna z dvoch najd\u00f4le\u017eitej\u0161\u00edch \u00fa\u010dinn\u00fdch l\u00e1tok z konope je antipsychotikom\r\n-CBD dok\u00e1\u017ee potla\u010di\u0165 sympt\u00f3my schizofr\u00e9nie v\u010faka tomu, \u017ee dok\u00e1\u017ee stabilizova\u0165 naru\u0161en\u00e9 alebo postihnut\u00e9 NMDA receptory\r\n-konkr\u00e9tny vedeck\u00fd v\u00fdskum potvrdzuje, \u017ee CBD m\u00e1 porovnate\u013en\u00fd antipsychotick\u00fd \u00fa\u010dinok s liekom amisulpridom pri ak\u00fatnej paranoidnej schizofr\u00e9nii\r\n-kanabidiol nem\u00e1 na rozdiel od in\u00fdch antipsychot\u00edk takmer \u017eiadne ved\u013eaj\u0161ie \u00fa\u010dinky (ako je napr. priberanie na v\u00e1he, zv\u00fd\u0161en\u00e1 hladina prolakt\u00ednu)\r\n-Izraelsk\u00ed vedci vy\u0161\u013eachtili druh konope, ktor\u00fd m\u00e1 vysok\u00fd obsah CBD a nem\u00e1 takmer \u017eiaden obsah THC. V krajin\u00e1ch EU by bolo tak\u00e9to druhy ve\u013emi jednoduch\u00e9 pestova\u0165 na poliach, \u010do sa aj vyu\u017e\u00edva\r\n-v Kanade a v USA na feder\u00e1lnej \u00farovni je CBD pova\u017eovan\u00e9 za neleg\u00e1lnu l\u00e1tku, \u010do je ale naprosto \u0161ialen\u00e9. CBD nem\u00e1 \u017eiadne psychoakt\u00edvne \u00fa\u010dinky. Z\u00e1kaz vych\u00e1dza zrejme z tej &#8220;logiky&#8221;, \u017ee THC a CBD maj\u00fa ur\u010dit\u00fa podobnos\u0165 v molekul\u00e1rnej \u0161trukt\u00fare\r\n<h2><span class=\"ez-toc-section\" id=\"THC_%E2%80%93_Tetrahydrocannabinol\"><\/span><strong>THC &#8211; Tetrahydrocannabinol<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n-THC, podobne ako canabidiol, i ke\u010f s menej \u00fa\u010dinne, je alosterick\u00fd modul\u00e1tor na \u03bc- a \u03b4-opioidn\u00e9 receptory\r\n-5-HT antagonista\r\n-NMDA antagonista\r\n-GABA antagonista\r\n-existuje v\u00fdskum, \u017ee pri n\u00edzkych d\u00e1vkach sa m\u00f4\u017ee THC spr\u00e1va\u0165 ako seroton\u00ednov\u00fd agonista. To znamen\u00e1, \u017ee THC sa m\u00f4\u017ee spr\u00e1va\u0165 nevyspytate\u013ene &#8211; chv\u00ed\u013eami m\u00f4\u017ee sp\u00f4sobova\u0165 \u0165a\u017ek\u00e9 depresie a chv\u00ed\u013eami n\u00e1ladu zlep\u0161ova\u0165.\r\n<em>-Pozn\u00e1mka na okraj<\/em>: mimochodom aj \u0161alvia lek\u00e1rska obsahuje \u00fa\u010dinn\u00e9 l\u00e1tky, ktor\u00e9 maj\u00fa spolo\u010dn\u00fa vlastnos\u0165 s THC, \u017ee s\u00fa antagonisti na GABA a seroton\u00ednov\u00e9 receptory.\r\n<h2><span class=\"ez-toc-section\" id=\"CBG_%E2%80%93_Cannabigerol_a_alfa2_receptor\"><\/span><strong>CBG &#8211; Cannabigerol a alfa2 receptor<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\n&#8211;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Cannabigerol\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Cannabigerol<\/a>\r\n-CBG sa nevyskytuje v druhoch, ktor\u00e9 maj\u00fa vysok\u00fd obsah THC, ale t\u00e1to \u00fa\u010dinn\u00e1 l\u00e1tka ma zaujala obzvl\u00e1\u0161\u0165\r\n-m\u00e1 n\u00edzku afinitu na 5-HT, CB1 a CB2 receptory\r\n-je siln\u00fd agonista na adrenal\u00edn alfa dva receptory, high affinity \u03b12-adrenergic receptor agonist <a href=\"https:\/\/en.wikipedia.org\/wiki\/Alpha-2_adrenergic_receptor\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Alpha-2_adrenergic_receptor<\/a>\r\n-\u03b12 receptory s\u00fa s pomedzi v\u0161etk\u00fdch ostatn\u00fdch druhov receptorov v\u00fdnimo\u010dn\u00e9 t\u00fdm, \u017ee ich zv\u00fd\u0161enou aktivitou sa krvn\u00fd tlak zn\u00ed\u017ei. Pri v\u0161etk\u00fdch ostatn\u00fdch adrenal\u00ednov\u00fdch receptoroch sa zv\u00fd\u0161en\u00edm aktivity tlak zv\u00fd\u0161i\r\n-zv\u00fd\u0161en\u00edm aktivity \u03b12 receptorom sa za\u010dne hladina noradrenal\u00ednu a jemu podobn\u00fdch l\u00e1tok, katecholam\u00ednov, zni\u017eova\u0165\r\n-lieky p\u00f4sobiace na alfa2 receptory p\u00f4sobia v mozgu.\r\nS\u00fa napr. lieky\r\nklonid\u00edn\/clonidine <a href=\"https:\/\/en.wikipedia.org\/wiki\/Clonidine\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Clonidine<\/a>\r\nguanfac\u00edn, <a href=\"https:\/\/en.wikipedia.org\/wiki\/Guanfacine\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Guanfacine<\/a>\r\ndexmedetomid\u00edn <a href=\"https:\/\/www.adc.sk\/databazy\/produkty\/detail\/dexdor-100-mikrogramov-ml-infuzny-koncentrat-606320.html\" target=\"_blank\" rel=\"noopener\">https:\/\/www.adc.sk\/databazy\/produkty\/detail\/dexdor-100-mikrogramov-ml-infuzny-koncentrat-606320.html<\/a>\r\nL\u00e1tky\/lieky, ktor\u00e9 s\u00fa agonisti na alfa2 receptory maj\u00fa nasledovn\u00e9 vyu\u017eitie:\r\n&#8211;<strong>proti hypertenzii<\/strong>, na srdcov\u00e9 probl\u00e9my (\u00fa\u010dinkami s\u00fa podobn\u00e9 ako betoblok\u00e1tori)\r\n-ako anest\u00e9za, ktor\u00fa pou\u017e\u00edvaj\u00fa veterin\u00e1ri, na uspatie zviera\u0165a (ved\u013eaj\u0161\u00ed \u00fa\u010dinok liekov p\u00f4sobiacich na alfa2 receptory je pr\u00e1ve ospalos\u0165)\r\n-lieky p\u00f4sobiace na alfa2 receptory maj\u00fa aj psychiatrick\u00e9 vyu\u017eitie ako je<strong> porucha pozornosti z hyperaktivitou<\/strong>\r\n-p\u00f4sobia na zlep\u0161enie pam\u00e4ti, zlep\u0161uj\u00fa s\u00fastredenos\u0165\r\n-ovplyv\u0148uj\u00fa \u010dinnos\u0165 hladk\u00fdch svalov\r\n-zni\u017euj\u00fa produkciu acetylchl\u00ednu\r\n-p\u00f4sobia proti<strong> \u00fazkostiam<\/strong> a<strong> posttraumatickej stresovej poruche<\/strong>\r\n<strong>Tak\u017ee \u00fa\u010dinn\u00e1 l\u00e1tka konope Cannabigerol<\/strong><strong> m\u00e1 hore uveden\u00e9 lie\u010debn\u00e9 indik\u00e1cie. Jej vyu\u017eitie je naozaj \u0161irok\u00e9<\/strong>\r\n<strong>Z\u00e1verom:<\/strong> rozhodne je treba urobi\u0165 maximum aby sa mohli slobodne a bez obmedzen\u00ed robi\u0165 vedeck\u00e9 v\u00fdskumy na konope a aby konope nebola nijak obmedzovan\u00e1 na lie\u010debn\u00e9 \u00fa\u010dely. Na politikov a \u00faradn\u00edkov jednotliv\u00fdch \u0161t\u00e1tov s\u00fa vyv\u00edjan\u00e9 ale siln\u00e9<strong> korup\u010dn\u00e9 tlaky zo strany farmaceutick\u00fdch firiem<\/strong>. Z korup\u010dn\u00fdch d\u00f4vodov sa len tak \u013eahko zmeny z\u00e1konov smerom k lep\u0161iemu neurobia. V \u010cesku bol vydan\u00fd z\u00e1kon, ktor\u00fd umo\u017e\u0148uje pou\u017e\u00edva\u0165 konope na lie\u010debn\u00e9 \u00fa\u010dely. Av\u0161ak \u00faradn\u00edci so S\u00daKL o\u010dividne boli podplaten\u00ed farmaceutick\u00fdmi firmami a preto urobili najv\u00e4\u010d\u0161ie mo\u017en\u00e9 prek\u00e1\u017eky a obmedzenia pre lie\u010dbu konopou. Pois\u0165ov\u0148a v \u010cesku lie\u010dbu konopou neprepl\u00e1ca a konope (ktor\u00e1 je v\u0161etka dov\u00e1\u017ean\u00e1 z Izraelu) je ve\u013emi drah\u00e1.\r\n******************************************************************\r\n<strong>Dodato\u010dn\u00e9 upresnenia ku konope:<\/strong>\r\n<em>Oprava k predch\u00e1dzaj\u00facemu \u010dl\u00e1nku:<\/em> konope nie je inhib\u00edtor acetylchol\u00ednester\u00e1zy, ale antagonista acetylchol\u00ednov\u00fdch receptorov.<br \/><br \/>Antagonista acetylchol\u00ednov\u00fdch receptorov sa prejav\u00ed napr. suchom v \u00fastach u rekrea\u010dn\u00e9ho u\u017e\u00edvate\u013ea konope.\r\nInhib\u00edcia muskar\u00edn-acetylchol\u00ednov\u00fdch receptorov sa prejav\u00ed tie\u017e aj zhor\u0161en\u00edm kognit\u00edvnych schopnost\u00ed, zhor\u0161en\u00edm kr\u00e1tkodobej, pracovnej \u010di dlhodobej pam\u00e4te. Siln\u00e1 inhib\u00edcia acetylchol\u00ednov\u00fdch receptorov sa prejav\u00ed podobne ako otrava \u013eu\u013ekom zlomocn\u00fdm, realistick\u00fdmi halucin\u00e1ciami, \u010do m\u00f4\u017ee ma\u0165 tie\u017e pr\u00edznaky schizofr\u00e9nie (to k pr\u00edznakom schizofr\u00e9nie u u\u017e\u00edvate\u013eov konope, tie\u017e m\u00f4\u017ee hra\u0165 ur\u010dit\u00fd faktor).<br \/><br \/><strong>Lie\u010dba Alzheimerovej choroby s konope, bez inhib\u00edtora acetylchol\u00ednester\u00e1zy, preto m\u00f4\u017ee by\u0165 ne\u00faspe\u0161n\u00e1.<\/strong><br \/><br \/>Inhib\u00edtory acetylchol\u00ednester\u00e1zy, m\u00f4\u017ee ma\u0165 nasledovn\u00e9 viacer\u00e9 synonymick\u00e9 pomenovania pod\u013ea \u010dlenenia \u0160\u00daKL:\r\nParasympatomimetik\u00e1, Inhib\u00edtory chol\u00ednester\u00e1zy, Antichol\u00ednester\u00e1zy\r\n<a href=\"http:\/\/www.adcc.sk\/web\/humanne-lieky\/ATC-skupiny.html?atcopen=N06DA02#N06DA02\" target=\"_blank\" rel=\"noopener\">http:\/\/www.adcc.sk\/web\/humanne-lieky\/ATC-skupiny.html?atcopen=N06DA02#N06DA02<\/a>\r\n<a href=\"http:\/\/www.adcc.sk\/web\/humanne-lieky\/atc-skupiny\/n06da\/anticholinesterazy.html\" target=\"_blank\" rel=\"noopener\">http:\/\/www.adcc.sk\/web\/humanne-lieky\/atc-skupiny\/n06da\/anticholinesterazy.html<\/a>\r\n<a href=\"http:\/\/www.adcc.sk\/web\/humanne-lieky\/ATC-skupiny.html?sec=HL&amp;what=atctree&amp;ATC=N06&amp;col=1#N06\" target=\"_blank\" rel=\"noopener\">http:\/\/www.adcc.sk\/web\/humanne-lieky\/ATC-skupiny.html?sec=HL&amp;what=atctree&amp;ATC=N06&amp;col=1#N06<\/a><br \/><br \/>V r\u00e1mci hospitaliz\u00e1cie kv\u00f4li psych\u00f3ze po po\u017eit\u00ed konope sa pacientovi pod\u00e1vj\u00fa nasledovn\u00e9 lieky :\r\n-agonista na GABA receptory. (Napr. liek zo skupiny benzodiazep\u00ednov\/sedat\u00edv alebo valpro\u00e1t\/kyselina valproov\u00e1) <a href=\"https:\/\/en.wikipedia.org\/wiki\/Valproate#Mechanism_of_action\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Valproate#Mechanism_of_action<\/a>\r\n<a href=\"http:\/\/www.adcc.sk\/web\/humanne-lieky\/atc-skupiny\/n03ag01\/kyselina-valproova.html\" target=\"_blank\" rel=\"noopener\">http:\/\/www.adcc.sk\/web\/humanne-lieky\/atc-skupiny\/n03ag01\/kyselina-valproova.html<\/a>\r\n-vhodn\u00fd je aj liek ktor\u00fd je agonista na acetylchol\u00ednove receptory (tie s\u00fa u\u017e uveden\u00e9 hore)\r\n-blok\u00e1tor opioidn\u00fdch receptorov\r\n-prekurzor seroton\u00ednu tryptof\u00e1n\r\n-antagonista na D1 recetor, antipsychotikum. (Konope je agonista na D1 receptor). Antipsychotikum da\u0165 pacientovi nie je pod\u013ea m\u0148a potrebn\u00e9 (aj ke\u010f neu\u0161kod\u00ed), hore uveden\u00e9 lieky by mali sta\u010di\u0165. (Samozrejme, \u017ee je ale ve\u013emi d\u00f4le\u017eit\u00e9 pou\u017ei\u0165 len tak\u00e9 antipsychotikum, ktor\u00e9 je agonista nie antagonista na seroton\u00ednov\u00e9 receptory). Samozrejme ak sa preuk\u00e1\u017ee, \u017ee m\u00e1 pacient trval\u00fa psych\u00f3zu, je vhodn\u00e9 aby u\u017e\u00edval antipsychotikum a to dlhodobo<br \/><br \/><a href=\"https:\/\/en.wikipedia.org\/wiki\/Cannabis_and_memory#Dopamine\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Cannabis_and_memory#Dopamine<\/a> (konope p\u00f4sob\u00ed na D1 receptor a je antagonista na acetylchol\u00ednov\u00e9 receptory)\r\n<a href=\"https:\/\/en.wikipedia.org\/wiki\/Cannabis_%28drug%29\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Cannabis_(drug)<\/a> (konope sp\u00f4sobuje sucho v \u00fastach)\r\n*********************************************************\r\n<h2><span class=\"ez-toc-section\" id=\"Inhibitor_acetylcholinesterazy\"><\/span><strong>Inhib\u00edtor acetylchol\u00ednester\u00e1zy<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\nZauj\u00edmav\u00e9 v\u00fdsledky luc\u00eddnych snov alebo astr\u00e1lneho cestovania by zrejme bolo pri kombin\u00e1cii<strong> konope<\/strong> a<strong> inhib\u00edtore acetylchol\u00ednester\u00e1zy<\/strong>. Liek zpel\u0161uje bdelos\u0165 a kr\u00e1tkodob\u00fa pam\u00e4\u0165 \u010do preh\u013abi a skvalitn\u00ed z\u00e1\u017eitok. Tie\u017e sa tak vyblokuj\u00fa ved\u013eaj\u0161ie \u00fa\u010dinky konope ako such\u00fd jazyk, such\u00e9 o\u010di, oslabenie kr\u00e1tkodobej a opera\u010dnej pam\u00e4te\r\n<h2><span class=\"ez-toc-section\" id=\"Inhibitor_acetylcholinesterazy_parasympatimymetikum_Anticholinesteraza\"><\/span><strong>Inhib\u00edtor acetylchol\u00ednester\u00e1zy, parasympatimymetikum, Antichol\u00ednester\u00e1za<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\nR\u00f4zne pomenovania pre rovnak\u00fd typ liekov. Ide o lieky s nesmierne \u0161irok\u00fdm vyu\u017eit\u00fdm v takmer v\u0161etk\u00fdch oblastiach medic\u00edny. Lieky maj\u00fa vyu\u017eitie dokonca aj v urol\u00f3gii (proti probl\u00e9mom pri zadr\u017eiavan\u00ed mo\u010du) a kardiol\u00f3gii (spoma\u013euj\u00fa frekvenciu srdca).\r\n<a href=\"https:\/\/www.adcc.sk\/web\/humanne-lieky\/atc-skupiny\/n07a\/parasympatomimetika.html\" target=\"_blank\" rel=\"noopener\">https:\/\/www.adcc.sk\/web\/humanne-lieky\/atc-skupiny\/n07a\/parasympatomimetika.html<\/a>\r\n<a href=\"https:\/\/www.adcc.sk\/web\/humanne-lieky\/atc-skupiny\/n06da\/anticholinesterazy.html\" target=\"_blank\" rel=\"noopener\">https:\/\/www.adcc.sk\/web\/humanne-lieky\/atc-skupiny\/n06da\/anticholinesterazy.html<\/a>\r\n<h2><span class=\"ez-toc-section\" id=\"Muskarin\"><\/span><strong>Muskar\u00edn<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\nRovnak\u00e9 \u00fa\u010dinky ako inhib\u00edtor acetylchol\u00ednester\u00e1zy m\u00e1 aj muskar\u00edn <a href=\"https:\/\/en.wikipedia.org\/wiki\/Muscarine\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Muscarine<\/a>. Tak\u017ee nie ste odk\u00e1zan\u00ed len na liek, ktr\u00fd sa zo\u017eenie \u0165a\u017eko. Je tam aj uveden\u00e9 v ak\u00fdch hub\u00e1ch sa vyskytuje. Muskar\u00edn je v kone\u010dnom d\u00f4sledku aj agonista na adenoz\u00ednov\u00e9 receptory, \u010do sa v praxi prejav\u00ed, \u017ee posiln\u00ed \u00fa\u010dinky konope\r\n<strong>\u010co robi\u0165 pri pred\u00e1vkovan\u00ed muskar\u00ednom?<\/strong>\r\nBu\u010fte opatrn\u00ed s d\u00e1vkovan\u00edm. Sledujte krvn\u00fd tlak a frekvenciu srdca. N\u00edzka frekvencia srdca a n\u00edzky krvn\u00fd tlak s\u00fa d\u00f4kazom pred\u00e1vkovania.\r\nAk budete ma\u0165 pocit na odpadnutie (synkopa), nie je to ni\u010d hrozn\u00e9, zosta\u0148te v posteli.\r\nProtijed pri pred\u00e1vkovan\u00ed m\u00f4\u017ee by\u0165 aj \u013eu\u013ekovec zlomocn\u00fd alebo durman.\r\nV nemocnici pri hospitaliz\u00e1cii (ak by ste sa tam rozhodli \u00eds\u0165) mus\u00edte lek\u00e1rom poradi\u0165 \u010do maj\u00fa s Vami robi\u0165 (lek\u00e1ri s\u00fa ve\u013emi hl\u00fapi) tak potrebujete pichn\u00fa\u0165 do \u017eily atrop\u00edn (resp. skopolam\u00edn) plus pr\u00edpadne adrenal\u00edn na normalizovanie krvn\u00e9ho tlaku a frekvencie srdca.\r\n<strong>Ale nechcem v\u00e1s stra\u0161i\u0165, ni\u010doho sa nemus\u00edte b\u00e1\u0165. Budete \u00faplne v pohode ak bude spr\u00e1vna d\u00e1vka huby (pri hube je probl\u00e9m, \u017ee neviete ko\u013eko \u00fa\u010dinnej l\u00e1tky obsahuje). Muskar\u00edn je na 100% bezpe\u010dn\u00e1 l\u00e1tka ak sa pou\u017eije v spr\u00e1vnej d\u00e1vke. V\u0161etko je z\u00e1vidsl\u00e9 od d\u00e1vky. Aj eutan\u00e1zia sa rob\u00ed s \u00faplne oby\u010dajn\u00fdmi liekmi, ktor\u00e9 sa be\u017ene pou\u017e\u00edvaj\u00fa, len s t\u00fdm rozdielom \u017ee sa pou\u017eije megad\u00e1vka. Ka\u017ed\u00fd liek m\u00f4\u017ee by\u0165 nebezpe\u010dn\u00fd vo vysokej d\u00e1vke<\/strong>\r\n<strong>Tak\u017ee kombin\u00e1cia konope a huby obsahuj\u00facej muskar\u00edn je rozumn\u00e1<\/strong>\r\n*********************\r\n<h2><span class=\"ez-toc-section\" id=\"Kombinacia_konope_a_alkoholu\"><\/span><strong>Kombin\u00e1cia konope a alkoholu<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\r\nJe sn\u00e1\u010f rozumn\u00e9 doda\u0165 aj k t\u00fdmto veciam nejak\u00e9 nov\u00e9 inform\u00e1cie.\r\nKombin\u00e1cia konope a alkoholu je mo\u017eno vn\u00edma\u0165 ako relat\u00edvne bezpe\u010dn\u00fa a rozumn\u00fa, ak sa dodr\u017eia ur\u010dit\u00e9 pravidl\u00e1.\r\nAlkohol posil\u0148uje \u00fa\u010dinok konope a\u017e trojit\u00fdmi mechanizmami. Nako\u013eko alkohol je agonista na adenoz\u00ednov\u00e9 receptory, pom\u00e1ho lep\u0161ie penetrova\u0165 ka\u017edej psychoakt\u00edvnej l\u00e1tke do mozgu, samozrejme vr\u00e1tane THC (\u00fa\u010dinnej l\u00e1tky konope).\r\nIn\u00fd v\u00fdskum hovor\u00ed, \u017ee alkohol sp\u00f4sobuje to, \u017ee \u010dlovek m\u00e1 omnoho viac THC v krvi.\r\n<a href=\"https:\/\/www.aacc.org\/media\/press-release-archive\/2015\/alcohol-combined-with-cannabis-significantly-increases-levels-of-thc-in-the-blood\" target=\"_blank\" rel=\"noopener\">https:\/\/www.aacc.org\/media\/press-release-archive\/2015\/alcohol-combined-with-cannabis-significantly-increases-levels-of-thc-in-the-blood<\/a>\r\nHlavn\u00e9 farmakologick\u00e9 \u00fa\u010dinky THC s\u00fa antagonizmus na GABA recepory a antagonizmus na NMDA receptory. Hlavn\u00e9 farmakologick\u00e9 \u00fa\u010dinky alkoholu s\u00fa agonizmus GABA recepory a antagonizmus na NMDA receptory. THC aj alkohol s\u00fa spolo\u010dne antagonisty na NMDA receptory, \u010do posiluje disociat\u00edvne farmakologick\u00e9 psychoakt\u00edvne \u00fa\u010dinky konope.\r\nV praxi to teda znamen\u00e1, \u017ee konope v\u00fdznamne pom\u00f4\u017ee zn\u00ed\u017ei\u0165 ved\u013eaj\u0161ie \u00fa\u010dinky konope a to s\u00fa depresie, ktor\u00e9 sa m\u00f4\u017eu vyskytova\u0165 pri jej u\u017e\u00edvan\u00ed relat\u00edvne \u010dasto.\r\nKonope tie\u017e zabr\u00e1ni a vyblokuje &#8220;pocit opojenia&#8221; u alkoholu &#8211; to je ve\u013emi pozit\u00edvne &#8211; alkohol je pre mnoh\u00fdch \u013eud\u00ed dos\u0165 n\u00e1vykov\u00e1 l\u00e1tka a konope tento n\u00e1vykov\u00fd potenci\u00e1l bezpe\u010dne zablokuje.\r\nCelkovo to v\u0161etko znamen\u00e1, \u017ee alkohol ve\u013emi silne zvy\u0161uje \u00fa\u010dinok konope. Preto pri tejto kombin\u00e1ci je treba si da\u0165 ve\u013emi v\u00fdznamne zn\u00ed\u017een\u00fa d\u00e1vku konope.\r\nTie\u017e kto m\u00e1 probl\u00e9m s n\u00edzkym krvn\u00fdm tlakom m\u00f4\u017ee ma\u0165 men\u0161\u00ed probl\u00e9m, preto\u017ee konope aj alkohol s\u00fa hypotenz\u00edvami &#8211; zni\u017euj\u00fa krvn\u00fd tlak, ale nie je to ni\u010d v\u00e1\u017ene.\r\nKombin\u00e1cia alkoholu s konope dos\u0165 v\u00fdznamne zmen\u00ed charakteristiku psychoakt\u00edvneho \u00fa\u010dinku konope. Je to ve\u013emi zauj\u00edmav\u00e1 a bezpe\u010dn\u00e1 kombin\u00e1cia, ak sa dodr\u017eia uveden\u00e9 pravidl\u00e1.\r\nAlkohol, nako\u013eko je GABA agonista, zlep\u0161\u00ed pr\u00edznaky k\u0155\u010dov u\u017e\u00edvate\u013ea konope s diagn\u00f3zou roztr\u00fasenej skler\u00f3zy (ktor\u00ed tie\u017e u\u017e\u00edvaj\u00fa konope na lie\u010dbu).<\/p>","protected":false},"excerpt":{"rendered":"Najviac rizikov\u00e9 je to s t\u00fdm \u010dlovekom, ktor\u00fd u\u017e\u00edva d\u00e1vku konope prv\u00fd kr\u00e1t. Po spr\u00e1vnosti mal by ma\u0165 zo za\u010diatku ve\u013emi opatrn\u00fa d\u00e1vku a d\u00e1vky postupne opatrne zvy\u0161ova\u0165. Tak radia \u013eudia, ktor\u00ed sa zaoberaj\u00fa lie\u010dbou konope. Ak si CNS na THC zvykne, potom to u\u017e za\u010d\u00edna by\u0165 v celku bezpe\u010dn\u00e9.","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-17","post","type-post","status-publish","format-standard","hentry","category-psychedelika"],"_links":{"self":[{"href":"https:\/\/filozofia.nett.to\/psychedelika\/wp-json\/wp\/v2\/posts\/17","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/filozofia.nett.to\/psychedelika\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/filozofia.nett.to\/psychedelika\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/filozofia.nett.to\/psychedelika\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/filozofia.nett.to\/psychedelika\/wp-json\/wp\/v2\/comments?post=17"}],"version-history":[{"count":0,"href":"https:\/\/filozofia.nett.to\/psychedelika\/wp-json\/wp\/v2\/posts\/17\/revisions"}],"wp:attachment":[{"href":"https:\/\/filozofia.nett.to\/psychedelika\/wp-json\/wp\/v2\/media?parent=17"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/filozofia.nett.to\/psychedelika\/wp-json\/wp\/v2\/categories?post=17"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/filozofia.nett.to\/psychedelika\/wp-json\/wp\/v2\/tags?post=17"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}