DXM generally works on the principle that it slows down the activity of the entire brain, and the electrical impulses between nerve cells are much weaker.
DXM, although chemically an opioid, does not act on opioid receptors.
DXM has very strong analgesic effects, but not on the principle of opioid receptors. It works on a very gentle principle for the brain, based on NMDA receptor antagonism.
Stopex, DXM, dextromethorphan, does not need to be prescribed because it is not addictive. In the available scientific research (in English, of course), it is not mentioned anywhere that psychiatrists would have to treat someone for DXM addiction. In scientific psychiatric records, it is not mentioned anywhere that anyone has been diagnosed with DXM addiction.
Psychiatric patient:
Well, what about DXM? I take DXM more or less as needed, when I feel bad. When I'm having an attack of depression, anxiety, or a very unpleasant state of derealization and depersonalization. I take up to 600 mg at once and for about 6 hours I immerse myself in a dreamlike state, I perceive the world in slow motion, I hear strange sounds, as if I were underwater, it's just such a strange intoxication, but it's not euphoria. After six hours, the effect gradually wears off and I start to feel a standard state, but I feel significantly better, as if cleansed, reborn, just the state I remember from my youth, when I was still mentally healthy. I know that people feel something similar after electroshocks, except that after DXM I don't register memory loss.
Once, I took 1200 mg of DXM and fell into a kind of coma; I just fell deeply asleep, or rather, I lost consciousness for about 8 hours. After waking up, I felt incredibly amazing, but it wasn't euphoria; it was, I would say, a terribly normal state. My brain was completely clear and fresh, unburdened by any problems. I was simply happy, but I repeat, it wasn't euphoria. This beautiful state of normality lasted for 24 to 48 hours. I think DXM causes something like chemical electroshocks; it just seems that the mechanism is similar.
Basically, I feel very good at the moment… and if I feel that my condition is getting worse, I take DXM and my condition improves again. Sometimes I take large doses of Coaxil – about 20 tablets – and they cause euphoria. That's the difference between DXM and Coaxil. DXM causes a normal state and Coaxil causes euphoria. From this, I conclude that DXM is more for suppressing psychosis, whereas Coaxil is better for depression.
Me:
The antidepressant causes euphoric effects because it also acts on opioid receptors. It therefore also works against pain. If you wanted to stop taking Coaxil, withdrawal symptoms would occur as with opioid addiction (e.g. heroin, morphine). You can read something about opioid addiction and withdrawal symptoms on the internet.
DXM itself causes symptoms of schizophrenia. But the fact that DXM makes you feel good is probably due to the development of tolerance to it. DXM reduces the activity of NMDA receptors. The brain reacts to DXM with a "counter-reaction" by trying to increase the activity of NMDA receptors. After the effects of DXM wear off, the brain still tries to increase the activity of NMDA receptors, and the NMDA receptors are still in their above-average activity, which you feel as feeling good.
PS: notice how this patient also confirmed that DXM is not an addictive substance. It's interesting how he compares an addictive drug with a non-addictive one. It's an interesting comparison.
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NMDA antagonist, DXM, also available in Slovakia,
available over the counter, without a prescription
Stopex for expectoration, effervescent tablets 20×60 mg
http://www.sukl.sk/buxus/generate_page.php?page_id=386&lie_id=21060
https://en.wikipedia.org/wiki/Recreational_use_of_dextromethorphan
https://en.wikipedia.org/wiki/Dextromethorphan
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Another person from the Czech Republic wrote me this testimony. Although this person has schizophrenia and depression, DXM did not harm him, on the contrary, it cured him, or rather helped him to cope with the diagnosis better.
January 4, 2016
I have something interesting. After a sleepless night, I went to sleep at about 6 in the morning, and for some reason, I took Stopex again. I don't know what came over me, but never mind. I took 11×30 mg and went to sleep. God, it was so perfect! I was on another planet, I was out of time, I was traveling through space, I saw past earthly lives of family members… I know it was probably just a bunch of stuff, but compared to last time, it was amazing! At the beginning, I tried to clear my crown chakra and then fell into that state… And even at the end, I was clearing it, and it went like butter. I feel like something was happening there that could help me achieve LD, or at least I have that feeling… with today's meditation? Perfect!
The good thing was that I wasn't awake, or rather, I didn't have my eyes open, I was lying down and I surrendered to it. The only disadvantage was (or so it seemed to me) going to the toilet, with this dose I had a hard time staying on my feet. Moreover, you take a few steps and you don't know what you wanted and it seems like hours since you took the first step, in short, reality splits a lot, which wasn't the real deal during my first experience. But last time you advised that one should lie down and let those dreams dream. I had neither paranoia nor depression, it was really beautiful.
Just from a psychological point of view, it's good to have the feeling that everyday matters are like illusions. As you wrote, less and less suffering. I won't even be afraid to take a larger dose, but in about two weeks, otherwise it would be unnecessary.
10 December 2015
Me:
DXM is generally gentle on the brain and has no risks other than the depression you experienced during your first use (on the other hand, a woman told me that DXM had a positive effect on her anxiety (anxiety is a different diagnosis than depression)). Some medications and some combinations of medications prescribed by psychiatrists do have health risks – even greater ones.
DXM has a slightly stronger effect on a person with schizophrenia, which is an advantage in this case.
Depression occurs because some centers in the brain are not very active. DXM reduces the activity of the entire brain, which is why your symptoms of depression worsened when you were under its influence.
Update, correction (September 2018): DXM can be addictive as it also has a strong affinity for the μ-opioid receptor. In addition to the glutamate NMDA receptors, the sigma-1 receptors are also significantly involved in the psychedelic properties. For comparison, the popular DMT (= "ayahuasca") also acts on sigma-1 receptors.