Every psychoactive substance and psychiatric drug works by increasing or decreasing the activity of a certain part of the brain. Some substances act on multiple types of receptors, and this in different intensities.
In antidepressants, drugs are mainly used to increase the activity of serotonin and noradrenaline receptors.
Antipsychotics reduce the activity of dopamine and serotonin receptors.
Most psychedelic substances increase the activity of mainly serotonin and sometimes dopamine receptors.
Cannabis affects almost the entire brain, reducing the activity of inhibitory GABA receptors (weakening their absorption capacity) and reducing the activity of excitatory NMDA receptors. In practice, the brain is in a more or less "balance" – it has neither increased nor decreased activity. Cannabis also acts on serotonin receptors, which can increase or decrease activity during one use – it is unpredictable. Cannabis has somewhat unpredictable effects and can affect everyone differently.
Psychedelic substances from the perspective of shamanism: the use of a psychedelic substance changes the activity of the chakras in a person.
The most suitable psychoactive substances for leaving the body
I see the greatest hope in substances that reduce the activity of NMDA receptors. https://en.wikipedia.org/wiki/NMDA_receptor_antagonist#Examples They are also called dissociative substances. Many of them are not on the list of banned substances, which is a great advantage – it would even be possible to do business with them legally. They are not addictive substances if the substance in question does not affect dopamine receptors in addition to NMDA.If a substance that is an NMDA antagonist has a so-called selective effect (meaning it acts exclusively on NMDA receptors), it is ideal. Some NMDA antagonists also act on dopamine receptors (increasing their activity), which is not good: dopamine receptors cause addiction and euphoria (e.g., the popular ketamine or phencyclidine (=PCP)). High activity of dopamine receptors could hypothetically also cause certain negative psychotic symptoms.
Many NMDA antagonists were also used as drugs, but they had to be discontinued due to side effects such as nightmares and hallucinations (according to the scientific materialistic dictionary). It is actually very positive that people were leaving their bodies even at low therapeutic doses.
Suitable selective NMDA antagonists are very safe and have no side effects.
A great advantage of NMDA antagonists is that they are very gentle on the brain because, unlike most psychedelics, they work by reducing the activity of certain parts of the brain. The brain is similar to, for example, an engine. If an electric motor runs at a lower power than it is designed for, nothing will happen to it, but if it runs at a higher power, it can break down. Therefore, NMDA antagonists are also suitable for more frequent use.
Dextromethorphan is not a suitable substance because it has a very low affinity: it requires a very high dose to achieve an effect. Tolerance also develops. Side effects such as occasional vomiting (although nowhere near as intense as with ayahuasca) are also due to the low affinity https://filozofia.nett.to/psychedelika/sk/stopex-dxm-dextrometorfan-nie-je-navykovy