Shocking results of scientific research: THC is not an addictive substance
I had an interesting idea: to look at scientific research on the addictiveness of THC – the active psychoactive substance in cannabis.
Cannabis can improve mood through serotonin receptors. If someone is in a state of "euphoria" when under the influence of cannabis (e.g., having fits of laughter and the like), this does not mean that it is an addictive substance. There is no scientific research linking addiction to serotonin receptors. The so-called feeling of reward – or the mechanism of all addictive substances – is exclusively associated with dopamine receptors. The problem, however, is that there are laboratory scientific studies that prove that THC does not increase the activity of dopamine receptors. There are also studies that cannabis cannot "cause" schizophrenia through dopamine receptors because it does not increase their activity.
As for scientific research, I have only found that addiction can only occur to marijuana, not THC. There is no scientific study that proves the addictiveness of THC. However, the catch in marijuana addiction is that marijuana is almost always mixed with tobacco, otherwise it would not burn properly and would be practically unusable. And nicotine, according to scientific studies, is very highly addictive. In marijuana, tobacco causes addiction, not cannabis. These facts were confirmed, for example, by a man with very diverse practical experience with cannabis, a guest on Slobodný vysielač, Zdeněk Majzlík, that in marijuana, tobacco is more addictive than cannabis.
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NIDA. Interesting facts
The most important anti-drug and scientific organization is called NIDA, its website is https://www.drugabuse.gov/
It is an official government organization.
This most powerful anti-drug organization is controversial because it participates in and finances drug research (i.e., volunteers must be "drugged" during research) and also supports and finances cannabis research for medical treatment purposes. They comment on this issue, for example, at these links: https://www.drugabuse.gov/about-nida/legislative-activities/testimony-to-congress/2014/mixed-signals-administrations-policy-marijuana-part-four-scientific-focus-adverse-health (here it is marginally, but still).
https://www.drugabuse.gov/drugs-abuse/marijuana/nidas-role-in-providing-marijuana-research
https://www.drugabuse.gov/drugs-abuse/marijuana/marijuana-cannabinoid-research-nida
NIDA's statement on the issue of addiction
https://www.drugabuse.gov/about-nida/legislative-activities/testimony-to-congress/2014/mixed-signals-administrations-policy-marijuana-part-four-scientific-focus-adverse-health
A speculative, controversial scientific theory or consideration that cannabis causes an "addictive" "reward feeling" through non-psychoactive CB2 receptors, which only affect immunity. Only CB1 receptors are "psychoactive".
https://www.drugabuse.gov/news-events/latest-science/cannabinoid-cb2-receptors-in-brain-reward-systems
https://www.drugabuse.gov/drugs-abuse/marijuana
Mental Disorders Versus Cannabis
The latest scientific study from February 2016 questions and critically approaches previous research suggesting that cannabis can "contribute" to mental disorders. It speaks of hasty conclusions and perceives the issue of whether THC can "contribute" to mental disorders or trigger them as ambiguous, leaving it open for further research.
These facts are also confirmed by the authentic testimony of a person with whom I am in contact: he has been diagnosed with proper schizophrenia and yet from time to time he smokes cannabis, sometimes not in the smallest doses. It does not worsen his mental disorder in any way, so he has no reason not to use cannabis from time to time.
As far as I know, scientific research has been done on the treatment of schizophrenia with cannabis, and the results for some types of schizophrenia were not the worst.
https://www.drugabuse.gov/news-events/latest-science/marijuana-use-raises-sud-risk
I had an interesting idea: to look at scientific research on the addictiveness of THC – the active psychoactive substance in cannabis.
Cannabis can improve mood through serotonin receptors. If someone is in a state of "euphoria" when under the influence of cannabis (e.g., having fits of laughter and the like), this does not mean that it is an addictive substance. There is no scientific research linking addiction to serotonin receptors. The so-called feeling of reward – or the mechanism of all addictive substances – is exclusively associated with dopamine receptors. The problem, however, is that there are laboratory scientific studies that prove that THC does not increase the activity of dopamine receptors. There are also studies that cannabis cannot "cause" schizophrenia through dopamine receptors because it does not increase their activity.
As for scientific research, I have only found that addiction can only occur to marijuana, not THC. There is no scientific study that proves the addictiveness of THC. However, the catch in marijuana addiction is that marijuana is almost always mixed with tobacco, otherwise it would not burn properly and would be practically unusable. And nicotine, according to scientific studies, is very highly addictive. In marijuana, tobacco causes addiction, not cannabis. These facts were confirmed, for example, by a man with very diverse practical experience with cannabis, a guest on Slobodný vysielač, Zdeněk Majzlík, that in marijuana, tobacco is more addictive than cannabis.
***************
NIDA. Interesting facts
The most important anti-drug and scientific organization is called NIDA, its website is https://www.drugabuse.gov/
It is an official government organization.
This most powerful anti-drug organization is controversial because it participates in and finances drug research (i.e., volunteers must be "drugged" during research) and also supports and finances cannabis research for medical treatment purposes. They comment on this issue, for example, at these links: https://www.drugabuse.gov/about-nida/legislative-activities/testimony-to-congress/2014/mixed-signals-administrations-policy-marijuana-part-four-scientific-focus-adverse-health (here it is marginally, but still).
https://www.drugabuse.gov/drugs-abuse/marijuana/nidas-role-in-providing-marijuana-research
https://www.drugabuse.gov/drugs-abuse/marijuana/marijuana-cannabinoid-research-nida
NIDA's statement on the issue of addiction
https://www.drugabuse.gov/about-nida/legislative-activities/testimony-to-congress/2014/mixed-signals-administrations-policy-marijuana-part-four-scientific-focus-adverse-health
A speculative, controversial scientific theory or consideration that cannabis causes an "addictive" "reward feeling" through non-psychoactive CB2 receptors, which only affect immunity. Only CB1 receptors are "psychoactive".
https://www.drugabuse.gov/news-events/latest-science/cannabinoid-cb2-receptors-in-brain-reward-systems
https://www.drugabuse.gov/drugs-abuse/marijuana
Mental Disorders Versus Cannabis
The latest scientific study from February 2016 questions and critically approaches previous research suggesting that cannabis can "contribute" to mental disorders. It speaks of hasty conclusions and perceives the issue of whether THC can "contribute" to mental disorders or trigger them as ambiguous, leaving it open for further research.
These facts are also confirmed by the authentic testimony of a person with whom I am in contact: he has been diagnosed with proper schizophrenia and yet from time to time he smokes cannabis, sometimes not in the smallest doses. It does not worsen his mental disorder in any way, so he has no reason not to use cannabis from time to time.
As far as I know, scientific research has been done on the treatment of schizophrenia with cannabis, and the results for some types of schizophrenia were not the worst.
https://www.drugabuse.gov/news-events/latest-science/marijuana-use-raises-sud-risk
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A very interesting video about how cannabis suppressed the symptoms of tremor and dyskinesia in a Parkinson's patient in 3 minutes. It's as if a miracle happened http://www.mojevideo.sk/video/290b3/ucinky_marihuany_na_parkinsonovu_chorobu.html Just my comment on the video: cannabis as a CB1 receptor agonist is an antagonist of acetylcholine receptors, which means that cannabis, among its many effects, also has the same effect as one of the main types of Parkinson's drugs: antagonists or blockers of acetylcholine receptors. Just for interest, it is exactly the same effect as that of deadly nightshade. For a Parkinson's patient, deadly nightshade in the right doses is also an excellent treatment without side effects. https://www.adc.sk/databazy/produkty/klasifikacia/HLN04A/anticholinergika.html?nai=1&ord=a1