{"id":9,"date":"2016-03-06T17:32:41","date_gmt":"2016-03-06T16:32:41","guid":{"rendered":"https:\/\/filozofia.nett.to\/farmakologia\/2016\/03\/06\/liecba-alzheimerovej-choroby-memantin\/"},"modified":"2026-02-02T14:42:14","modified_gmt":"2026-02-02T13:42:14","slug":"liecba-alzheimerovej-choroby-memantin","status":"publish","type":"post","link":"https:\/\/filozofia.nett.to\/farmakologia\/sk\/liecba-alzheimerovej-choroby-memantin\/","title":{"rendered":"Lie\u010dba Alzheimerovej choroby: memant\u00edn"},"content":{"rendered":"

Hlavn\u00fd a najd\u00f4le\u017eitej\u0161\u00ed \u00fa\u010dinok memant\u00ednu je NMDA antagonizmus. Biologick\u00fd pol\u010das m\u00e1 60-100 hod\u00edn, preto je nevhodn\u00fd na rekrea\u010dn\u00e9 pou\u017eitie ako droga.
\r\nhttps:\/\/en.wikipedia.org\/wiki\/Memantine<\/a>
\r\nhttps:\/\/en.wikipedia.org\/wiki\/NMDA_receptor_antagonist<\/a>
\r\nPri lie\u010dbe Alzheimerovej choroby<\/strong> v\u00fdlu\u010dne liekom memant\u00ednom<\/strong>, bez inhib\u00edtora acetylchol\u00ednester\u00e1zy, bude lie\u010dba ne\u00fa\u010dinn\u00e1, nako\u013eko memant\u00edn m\u00e1 negat\u00edvny ved\u013eaj\u0161\u00ed \u00fa\u010dinok antagonizmu na acetylchol\u00ednov\u00e9 receptory. D\u00e1vka lieku zo skupiny antichol\u00ednester\u00e1zy sa mus\u00ed zvy\u0161ova\u0165 a\u017e do vtedy, k\u00fdm sa neza\u010dn\u00fa prejavova\u0165 jeho ved\u013eaj\u0161ie \u00fa\u010dinky ako napr. nadmern\u00e9 slinenie, k\u0155\u010de v tr\u00e1viacej s\u00fastave, inkontinencia (d\u00e1vka mus\u00ed by\u0165 stanoven\u00e1 testne pod prejavovan\u00edm ved\u013eaj\u0161\u00edch \u00fa\u010dinkov).
\r\nhttps:\/\/en.wikipedia.org\/wiki\/Memantine#Cholinergic_.28nicotinic_acetylcholine_receptor.29<\/a>
\r\nhttps:\/\/en.wikipedia.org\/wiki\/Acetylcholinesterase_inhibitor<\/a>
\r\nVe\u013emi spr\u00e1vne je kombinova\u0165 memant\u00edn s liekom v<\/strong>arenikl\u00edn<\/strong> https:\/\/en.wikipedia.org\/wiki\/Varenicline<\/a>
\r\nhttps:\/\/cs.wikipedia.org\/wiki\/Vareniklin<\/a>
\r\nhttps:\/\/www.adcc.sk\/web\/humanne-lieky\/atc-skupiny\/n07ba03\/vareniklin.html<\/a>
\r\nMemant\u00edn <\/strong>p\u00f4sob\u00ed proti excitoxicite, preto je ho potrebn\u00e9 pou\u017e\u00edva\u0165 u\u017e v \u00faplne za\u010diato\u010dnom \u0161t\u00e1diu Alzheimerovej choroby<\/strong> (preto\u017ee v pokro\u010dilom \u0161t\u00e1diu choroby je u\u017e ve\u013emi ale ve\u013emi neskoro), ale aj v pr\u00edpade ak nie s\u00fa splnen\u00e9 v\u0161etky diagnostick\u00e9 krit\u00e9ria na Alzheimerovu chorobu (ako prevencia). Neexistuje \u017eiadne empirick\u00e9, racion\u00e1lne a logick\u00e9 vysvetlenie, ako m\u00f4\u017ee pom\u00e1ha\u0165 memant\u00edn na kognit\u00edvne schopnosti v pokro\u010dilom \u0161t\u00e1diu choroby na b\u00e1ze excitoxicity. Memant\u00edn m\u00f4\u017ee degener\u00e1ciu excitoxicitou len spomali\u0165 alebo pozastavi\u0165. V pokro\u010dilom \u0161t\u00e1diu pom\u00e1ha\u0165 pacientovi memant\u00ednom je u\u017e neskoro.
\r\nLek\u00e1ri na Slovensku ani nevedia \u010do je to excitoxicita, preto\u017ee je treba ve\u013ea \u0161tudova\u0165 https:\/\/en.wikipedia.org\/wiki\/Excitotoxicity<\/a>
\r\nOfici\u00e1lne m\u00e1 memant\u00edn indik\u00e1ciu len v stredne \u0165a\u017ekom a\u017e \u0165a\u017ekom \u0161t\u00e1diu choroby. Je to z toho d\u00f4vodu, lebo sa robili len kr\u00e1tkodob\u00e9 a m\u00e1lo rozsiahle vedeck\u00e9 \u0161t\u00fadia na to, aby sa mohol priamo dok\u00e1za\u0165 aj priazniv\u00fd \u00fa\u010dinok memant\u00ednu v za\u010diato\u010dnom \u0161t\u00e1diu choroby.
\r\nPri v\u00fdskumoch sa zrejme preuk\u00e1zalo, \u017ee memant\u00edn zlep\u0161uje kognit\u00edvne schopnosti v stredne \u0165a\u017ekej a\u017e \u0165a\u017ekej chorobe. To by sa vedecky dalo vysvetli\u0165 t\u00fdm, \u017ee ved\u013eaj\u0161\u00ed \u00fa\u010dinok v\u0161etk\u00fdch NMDA antagonistov sp\u00f4sib\u00ed zv\u00e4\u010d\u0161enie objemu nervov\u00fdch buniek, kv\u00f4li tomu, \u017ee vakuoly t\u00fdchto buniek naber\u00fa viac vody. Nako\u013eko Alzheimerik m\u00e1 scvrknut\u00fd mozog, memant\u00edn mu objem mozgu zv\u00e4\u010d\u0161\u00ed. Objemovo scvrknut\u00fd mozog Alzheimerika, nie je schopn\u00fd robi\u0165 “Mexick\u00e9 vlny”, \u010do mu zhor\u0161uje jeho kognit\u00edvne schopnosti. Memant\u00edn mu objem mozgu zv\u00e4\u010d\u0161\u00ed, mozog za\u010dne by\u0165 schopn\u00fd mexick\u00fdch v\u013an a pacient za\u010dne ma\u0165 lep\u0161ie kognit\u00edvne schopnosti.
\r\n
\r\nPorovnanie Alzheimerick\u00e9ho a zdrav\u00e9ho mozgu
\r\nhttps:\/\/en.wikipedia.org\/wiki\/File:Alzheimer%27s_disease_brain_comparison.jpg<\/a>
\r\nVedeck\u00fd v\u00fdskum dokazuj\u00faci, \u017ee mexick\u00e9 vlny mozgu hraj\u00fa d\u00f4le\u017eit\u00fa \u00falohu v kognit\u00edvnych schopnostiach celkovo a v Alzheimerovej chorobe
\r\nhttp:\/\/www.sciencedaily.com\/releases\/2014\/11\/141118072634.htm<\/a>
\r\n
\r\nZv\u00e4\u010d\u0161enie objemu nervov\u00fdch buniek, ako ved\u013eaj\u0161\u00ed \u00fa\u010dinok NMDA antagonistov
\r\nhttps:\/\/en.wikipedia.org\/wiki\/NMDA_receptor_antagonist<\/a>
\r\nhttps:\/\/en.wikipedia.org\/wiki\/Olney%27s_lesions<\/a>
\r\n
\r\nVe\u013ekos\u0165 d\u00e1vky memant\u00ednu proti excitoxicite, pri prevent\u00edvnej indik\u00e1cii alebo pri \u013eah\u0161om \u0161t\u00e1diu Alzheimerovej choroby sta\u010d\u00ed aby bola mal\u00e1, \u010faleko men\u0161ia od toho, aby sa prejavovali z toho ved\u013eaj\u0161ie \u00fa\u010dinky halucin\u00e1cii.
\r\nTie\u017e pri vo\u013ebe ve\u013ekosti d\u00e1vky si lek\u00e1r mus\u00ed da\u0165 ve\u013ek\u00fd pozor, aby nedal vy\u0161\u0161iu d\u00e1vku, ako sa bud\u00fa prejavova\u0165 ved\u013eaj\u0161ie \u00fa\u010dinky halucin\u00e1cii. Pri\u010dom nemus\u00ed by\u0165 jednoduch\u00e9 rozl\u00ed\u0161i\u0165, \u010do s\u00fa to halucin\u00e1cie z memant\u00ednu a \u010do je to “Alzheimerick\u00e1 psych\u00f3za”<\/p>","protected":false},"excerpt":{"rendered":"Hlavn\u00fd a najd\u00f4le\u017eitej\u0161\u00ed \u00fa\u010dinok memant\u00ednu je NMDA antagonizmus. Memant\u00edn p\u00f4sob\u00ed proti excitoxicite, preto je ho potrebn\u00e9 pou\u017e\u00edva\u0165 u\u017e v \u00faplne za\u010diato\u010dnom \u0161t\u00e1diu Alzheimerovej choroby.","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-9","post","type-post","status-publish","format-standard","hentry","category-farmakologia"],"_links":{"self":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/posts\/9","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/comments?post=9"}],"version-history":[{"count":0,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/posts\/9\/revisions"}],"wp:attachment":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/media?parent=9"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/categories?post=9"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/tags?post=9"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}