{"id":44,"date":"2025-02-09T11:32:04","date_gmt":"2025-02-09T10:32:04","guid":{"rendered":"https:\/\/filozofia.nett.to\/farmakologia\/2025\/02\/09\/antipsychotika-kvetiapin-aripiprazol-sulpirid\/"},"modified":"2026-01-28T00:43:50","modified_gmt":"2026-01-27T23:43:50","slug":"antipsychotika-kvetiapin-aripiprazol-sulpirid","status":"publish","type":"post","link":"https:\/\/filozofia.nett.to\/farmakologia\/sk\/antipsychotika-kvetiapin-aripiprazol-sulpirid\/","title":{"rendered":"Antipsychotik\u00e1 Kvetiap\u00edn, Aripiprazol, Sulpirid"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/filozofia.nett.to\/farmakologia\/sk\/antipsychotika-kvetiapin-aripiprazol-sulpirid\/#Kvetiapin\" >Kvetiap\u00edn<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/filozofia.nett.to\/farmakologia\/sk\/antipsychotika-kvetiapin-aripiprazol-sulpirid\/#Aripiprazol\" >Aripiprazol<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/filozofia.nett.to\/farmakologia\/sk\/antipsychotika-kvetiapin-aripiprazol-sulpirid\/#Sulpirid\" >Sulpirid<\/a><\/li><\/ul><\/nav><\/div>\n<p>\n<p style=\"line-height: 100%; margin-bottom: 0cm;\"><strong><span style=\"background: transparent;\">Upozornenie. Pre pochopenie kontextu, tento \u010dl\u00e1nok som p\u00edsal predov\u0161etk\u00fdm v kontexte vhodnosti pacientov s bipol\u00e1rnou poruchou, hoci niektor\u00e9 \u010dasti \u010dl\u00e1nku s\u00fa viac univerz\u00e1lne<\/span><\/strong><\/p>\n<h2><span class=\"ez-toc-section\" id=\"Kvetiapin\"><\/span><strong>Kvetiap\u00edn<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Je antagonista na dopam\u00ednov\u00e9 a seroton\u00ednov\u00e9 receptory (antagonista to znamen\u00e1, \u017ee zni\u017euje \u00fa\u010dinky). Kombin\u00e1cia kvetiap\u00ednu s SSRI je nevhodn\u00e1 z d\u00f4vodu, \u017ee kvetiap\u00edn oslabuje v\u0161etky pozit\u00edvne \u00fa\u010dinky SSRI (antidepres\u00edvne a proti\u00fazkostn\u00e9 \u00fa\u010dinky). SSRI naopak funguje na princ\u00edpe, \u017ee zvy\u0161uje aktivitu v\u0161etk\u00fdm typom seroton\u00ednov\u00fdch receptorov.<br \/>Kvetiap\u00edn tie\u017e \u00fa\u010dinkuje ako antagonista na muskar\u00edn-acetylchol\u00ednov\u00e9 recoptory. M\u00e1 to svoje v\u00fdhody aj nev\u00fdhody. Zni\u017euje to negat\u00edvne ved\u013eaj\u0161ie \u00fa\u010dinky zn\u00ed\u017eenej aktivity dopam\u00ednov\u00fdch receptorov ako je svalov\u00fd tras a probl\u00e9my motorikou napr. stuhnutie n\u00f4h (\u010do s\u00fa tie\u017e pr\u00edznaky parkinsonovej choroby).<br \/>Nev\u00fdhoda antagonizmu na muskar\u00edn-acetylchol\u00ednov\u00e9 receptory je spomalenie procesu metabolizmu, spomalenie tr\u00e1venia \u010do m\u00e1 potenci\u00e1l vies\u0165 k priberaniu na v\u00e1he.<br \/>(Parkinsovon\u00ed pacienti, ktor\u00ed trpia n\u00edzkou aktivitou dopam\u00edov\u00fdch receptorov tie\u017e u\u017e\u00edvaj\u00fa antagonisty na muskar\u00edn-acetylchol\u00ednov\u00e9 receptory).<br \/>Ne\u017eiad\u00face \u00fa\u010dinky kvetiap\u00ednu je mo\u017en\u00e9 elimitova\u0165 lienkmi s opa\u010dn\u00fdmi \u00fa\u010dimkami z kateg\u00f3rie parasympatomimetikum.<br \/>Niektor\u00e9 antipsychotik\u00e1 naopak p\u00f4sobia ako agonisti na muskar\u00ednov\u00e9 receptory.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Aripiprazol\"><\/span><strong>Aripiprazol<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>M\u00e1 zauj\u00edmav\u00e9 \u00fa\u010dinky v tom, \u017ee niektor\u00fdm typom seroton\u00ednov\u00fdch a dopaminov\u00fdch receptorov \u00fa\u010dinky zvy\u0161uje in\u00fdm zni\u017euje (P\u00f4sob\u00ed na niektor\u00e9 podtypy t\u00fdchto receptorov ako aj agonista tak aj antagonista).<br \/>Kombin\u00e1cia s SSRI je nevhodn\u00e1, preto\u017ee na t\u00fdm podtypom seroton\u00ednov\u00fdch receptorov na ktor\u00e9 aripiprazol p\u00f4sob\u00ed ako agonista m\u00f4\u017ee zv\u00fd\u0161i\u0165 \u00fa\u010dinnos\u0165 aj 100 n\u00e1sobne.<br \/>Tie\u017e sa uk\u00e1zali ako ve\u013ek\u00e9 rozdiely v ne\u017eiad\u00facich \u00fa\u010dinkoch ktor\u00e9 typy SSRI sp\u00f4sobili men\u0161iu a ktor\u00e9 men\u0161iu paseku s liekov\u00fdmi interakciami s SSRI.<br \/>Aripiprazol je mo\u017en\u00e9 a vhodn\u00e9 kombinova\u0165 s buspir\u00f3nom, \u010do je lie\u010divo proti \u00fazkosti na inom princ\u00edpe ako SSRI.<br \/>Kombin\u00e1cia aripiprazolu a SSRI m\u00f4\u017ee prinies\u0165 halucin\u00e1cie.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Sulpirid\"><\/span><strong>Sulpirid<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>Pozit\u00edvum tohto antipsychotika je to, \u017ee sa d\u00e1 dobre kombinova\u0165 s SSRI, nako\u013eko nep\u00f4sob\u00ed na seroton\u00ednov\u00e9 receptory ale v\u00fdlu\u010dne na receptory dopam\u00ednov\u00e9. Psychiater m\u00e1 dovolen\u00e9 tak\u00fdto liek predp\u00edsa\u0165 aj bipol\u00e1rnemu pacientovi.\n<br \/>Re\u00e1lny zmysel bipol\u00e1rneho pacienta u\u017e\u00edva\u0165 tento liek m\u00e1 iba po\u010das manick\u00fdch epiz\u00f3d, kedy je aktivita dopam\u00ednov\u00fdch receptorov vy\u0161\u0161ia.<\/p>","protected":false},"excerpt":{"rendered":"Upozornenie. Pre pochopenie kontextu, tento \u010dl\u00e1nok som p\u00edsal predov\u0161etk\u00fdm v kontexte vhodnosti pacientov s bipol\u00e1rnou poruchou, hoci niektor\u00e9 \u010dasti \u010dl\u00e1nku s\u00fa viac univerz\u00e1lne Kvetiap\u00edn Je antagonista na dopam\u00ednov\u00e9 a seroton\u00ednov\u00e9 receptory (antagonista to znamen\u00e1, \u017ee zni\u017euje \u00fa\u010dinky). Kombin\u00e1cia kvetiap\u00ednu s SSRI je nevhodn\u00e1 z d\u00f4vodu, \u017ee kvetiap\u00edn oslabuje v\u0161etky pozit\u00edvne \u00fa\u010dinky SSRI (antidepres\u00edvne a proti\u00fazkostn\u00e9 &#8230; <a title=\"Antipsychotik\u00e1 Kvetiap\u00edn, Aripiprazol, Sulpirid\" class=\"read-more\" href=\"https:\/\/filozofia.nett.to\/farmakologia\/sk\/antipsychotika-kvetiapin-aripiprazol-sulpirid\/\" aria-label=\"Pre\u010d\u00edtajte si viac o Antipsychotik\u00e1 Kvetiap\u00edn, Aripiprazol, Sulpirid\">\u010c\u00edta\u0165 viac<\/a>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-44","post","type-post","status-publish","format-standard","hentry","category-farmakologia"],"_links":{"self":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/posts\/44","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/comments?post=44"}],"version-history":[{"count":0,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/posts\/44\/revisions"}],"wp:attachment":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/media?parent=44"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/categories?post=44"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/tags?post=44"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}