{"id":39,"date":"2025-02-09T11:12:02","date_gmt":"2025-02-09T10:12:02","guid":{"rendered":"https:\/\/filozofia.nett.to\/farmakologia\/2025\/02\/09\/guanfacin-klonidin-setrne-psychiatricke-lieky-zalozene-na-adrenalin-alfa-2-receptoroch-alpha-2-adrenergic-receptor-alpha-2-a2-adrenergic-receptor\/"},"modified":"2026-02-01T15:06:47","modified_gmt":"2026-02-01T14:06:47","slug":"guanfacin-klonidin-setrne-psychiatricke-lieky-zalozene-na-adrenalin-alfa-2-receptoroch-alpha-2-adrenergic-receptor-alpha-2-a2-adrenergic-receptor","status":"publish","type":"post","link":"https:\/\/filozofia.nett.to\/farmakologia\/sk\/guanfacin-klonidin-setrne-psychiatricke-lieky-zalozene-na-adrenalin-alfa-2-receptoroch-alpha-2-adrenergic-receptor-alpha-2-a2-adrenergic-receptor\/","title":{"rendered":"Guanfacin. Klonid\u00edn. \u0160etrn\u00e9 psychiatrick\u00e9 lieky zalo\u017een\u00e9 na adrenal\u00edn alfa 2 receptoroch. Alpha-2 adrenergic receptor, alpha-2 (\u03b12) adrenergic receptor"},"content":{"rendered":"

Guanfacin. Klonid\u00edn. \u0160etrn\u00e9 psychiatrick\u00e9 lieky zalo\u017een\u00e9 na adrenal\u00edn alfa 2 receptoroch. Alpha-2 adrenergic receptor, alpha-2 (\u03b12) adrenergic receptor<\/strong>\n
Pozit\u00edvum adrenal\u00edn alfa 2 receptorov je \u017ee maj\u00fa aj analgetick\u00fd \u00fa\u010dinok proti bolesti.\n
Niektor\u00e9 typy liekov p\u00f4sobiace na adrenal\u00edn alfa 2 receptory sa pou\u017e\u00edvaj\u00fa veterin\u00e1rnej medic\u00edne ako anestetikum (Medetomid\u00edn, Xylaz\u00edn). Vyu\u017eitie u \u013eud\u00ed ako anestetikum je v \u0161t\u00e1diu vedeck\u00fdch experimentov<\/a> ako liek pod pracovn\u00fdm n\u00e1zvom 4-NEMD.

Guanfacin<\/strong>
Guanfacin silne obmedzuje produkciu noradrenal\u00ednu v mozgu \u010d\u00edm obmedzuje m\u00e1niu a zni\u017euje krvn\u00fd tlak. V\u00fdborn\u00fd \u00fa\u010dinok pre podporu sp\u00e1nku. Najlep\u0161ie u\u017ei\u0165 tesne pred span\u00edm.
V \u010cR a SR guanfacin svojho \u010dasu pred\u00e1vala farma firma Takeda pod komer\u010dn\u00fdm n\u00e1zvom INTUNIV. Licenciu na predaj maj\u00fa st\u00e1le platn\u00fa, hoci v dod\u00e1vate\u013eskom re\u0165azci lek\u00e1rni \u010cR aktu\u00e1lne nie je dostupn\u00e1. Rozhodne m\u00e1 zmysel sa na to tejto firmy sp\u00fdta\u0165, \u010di a za ak\u00fdch podmienok je
schopn\u00e1 guanfacin individu\u00e1lne doda\u0165. Firma m\u00e1 pobo\u010dku aj v \u010cR.

Dexmedetomid\u00edn<\/strong>\n
Dexmedetomid\u00edn<\/a> je \u010do do princ\u00edpu fungovania agonista na adrenal\u00edn alfa dva receptory ur\u010den\u00fd pre bipol\u00e1rnych pacientov najm\u00e4 na pr\u00edznaky agit\u00e1cie<\/a>. Slovo agit\u00e1cia m\u00e1 v psychiatrickej terminol\u00f3gii \u0161pecifick\u00fd v\u00fdznam je to stav nepokoja.\n
Tento liek m\u00e1 \u0161irok\u00e9 vyu\u017eitie. V \u010cR alebo SR m\u00e1 \u017eia\u013e len limitovan\u00e9 pou\u017eitie a to len na oddelen\u00ed jednotky intenz\u00edvnej starostlivosti, \u010do rob\u00ed vyu\u017eitie tohto lieku na psychiatrickom oddelen\u00ed prakticky nere\u00e1lnym, hoci tam by sa najviac uplatnil. Ve\u013ek\u00e1 \u0161koda.\n
Dexmedetomid\u00edn je poskytovan\u00fd v\u00fdlu\u010dne v injek\u010dnej forme<\/a>.

Klonid\u00edn<\/strong>\n
Klonid\u00edn p\u00f4sob\u00ed ako agonista na adrenal\u00edn alfa dva receptory a na imidazol\u00ednov\u00e9 receptory \u010do ho rob\u00ed asi najsilnej\u0161\u00edm liekom na zn\u00ed\u017eenie krvn\u00e9ho tlaku. Agonizmus na imidazol\u00ednov\u00e9 receptory tie\u017e zodpoved\u00e1 za zn\u00ed\u017eenie krvn\u00e9ho tlaku ale nemaj\u00fa vplyv na psychiku. Guanfac\u00edn je lep\u0161\u00ed pre psychiatrick\u00fdch pacientov, preto\u017ee ved\u013eaj\u0161\u00ed \u00fa\u010dinok zn\u00ed\u017eenia krvn\u00e9ho tlaku nie je tak ve\u013ek\u00fd a p\u00f4sob\u00ed viac cielene.\n
Podarilo sa mi klonid\u00edn n\u00e1js\u0165 aj na \u010diernom trhu, ale nem\u00f4\u017eem tak\u00fdto eshop<\/a> odpor\u00fa\u010da\u0165.<\/p>","protected":false},"excerpt":{"rendered":"Guanfacin. Klonid\u00edn. \u0160etrn\u00e9 psychiatrick\u00e9 lieky zalo\u017een\u00e9 na adrenal\u00edn alfa 2 receptoroch. Alpha-2 adrenergic receptor, alpha-2 (\u03b12) adrenergic receptor Pozit\u00edvum adrenal\u00edn alfa 2 receptorov je \u017ee maj\u00fa aj analgetick\u00fd \u00fa\u010dinok proti bolesti. Niektor\u00e9 typy liekov p\u00f4sobiace na adrenal\u00edn alfa 2 receptory sa pou\u017e\u00edvaj\u00fa veterin\u00e1rnej medic\u00edne ako anestetikum (Medetomid\u00edn, Xylaz\u00edn). Vyu\u017eitie u \u013eud\u00ed ako anestetikum je v … \u010c\u00edta\u0165 viac<\/a>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-39","post","type-post","status-publish","format-standard","hentry","category-farmakologia"],"_links":{"self":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/posts\/39","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/comments?post=39"}],"version-history":[{"count":0,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/posts\/39\/revisions"}],"wp:attachment":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/media?parent=39"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/categories?post=39"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/tags?post=39"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}