{"id":151,"date":"2016-03-06T18:24:44","date_gmt":"2016-03-06T17:24:44","guid":{"rendered":"https:\/\/filozofia.nett.to\/farmakologia\/ambiguities-surrounding-guanfacine-and-clonidine-incorrect-naming-of-adrenaline-alpha-2-receptors\/"},"modified":"2026-02-04T13:14:37","modified_gmt":"2026-02-04T12:14:37","slug":"ambiguities-surrounding-guanfacine-and-clonidine-incorrect-naming-of-adrenaline-alpha-2-receptors","status":"publish","type":"post","link":"https:\/\/filozofia.nett.to\/farmakologia\/en\/ambiguities-surrounding-guanfacine-and-clonidine-incorrect-naming-of-adrenaline-alpha-2-receptors\/","title":{"rendered":"Ambiguities surrounding guanfacine and clonidine. Incorrect naming of adrenaline alpha 2 receptors"},"content":{"rendered":"<p>The drugs guanfacine and clonidine are agonists (they increase the activity) of adrenaline alpha 2 receptors, and yet this drug lowers the level of adrenaline in the brain and in the body, and lowers blood pressure. How is such a paradox possible?<br \/> <strong>The catch lies in a very gross error<\/strong> &#8211; even in cutting-edge science, mistakes are made: adrenaline alpha 2 receptors were mistakenly named &quot;adrenaline&quot; receptors, but the name has stuck. They should not be called &quot;adrenaline&quot; receptors &#8211; it&#39;s a mistake. The correct naming of receptors is based on the neurotransmitter substance to which the receptors are bound. The neurotransmitter substance of adrenaline alpha 2 receptors is not adrenaline. Therefore, when the activity of these receptors increases, blood pressure drops and adrenaline production in the brain decreases.<\/p><p> <a href=\"https:\/\/en.wikipedia.org\/wiki\/Alpha-2_adrenergic_receptor\" target=\"_blank\" rel=\"noopener\">https:\/\/en.wikipedia.org\/wiki\/Alpha-2_adrenergic_receptor<\/a><\/p>","protected":false},"excerpt":{"rendered":"The catch lies in a very gross error, even in top-notch science, mistakes are made.","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11],"tags":[],"class_list":["post-151","post","type-post","status-publish","format-standard","hentry","category-pharmacology"],"_links":{"self":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/posts\/151","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/comments?post=151"}],"version-history":[{"count":0,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/posts\/151\/revisions"}],"wp:attachment":[{"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/media?parent=151"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/categories?post=151"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/filozofia.nett.to\/farmakologia\/wp-json\/wp\/v2\/tags?post=151"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}