Psychiatry
And sometimes it can happen that a doctor performs "euthanasia" on a patient even unintentionally due to a lack of medical-pharmacological knowledge. Doctors follow the package inserts from the State Institute for Drug Control, and there are many professional inaccuracies, such as overestimation or underestimation or failure to mention some contraindications. A fatal combination of drugs is, for example, an MAO inhibitor (which can be a psychiatric or Parkinson's drug) with some dopamine agonists , which have a non-selective effect – a side effect with high affinity for serotonin receptors. In such a case, the activity of serotonin receptors is too high and the patient's heart will certainly not withstand it. It is better not to combine an MAO inhibitor with a dopamine agonist. I am afraid that from time to time it happens that a neurologist or geriatrician can unintentionally send a Parkinson's patient to the other world.
https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor
https://en.wikipedia.org/wiki/Dopamine_agonist
Furthermore, psychiatric patients are also on very thin ice if they are to be put to sleep under general anesthesia for surgery. I know that one type of general anesthesia, sevoflurane , used in the Slovak Republic, has the side effect of being a serotonin receptor agonist. If this anesthetic active substance were combined with any psychiatric medication that increases serotonin receptor activity, the patient would most likely not survive the operation. However, I am quite certain that anesthesiologists are unaware of this contraindication. In the best-case scenario, a catastrophic form of vomiting may occur, which can last up to 4 hours.
https://en.wikipedia.org/wiki/Sevoflurane#Pharmacology
https://www.ncbi.nlm.nih.gov/pubmed/20885002
https://www.ncbi.nlm.nih.gov/pubmed/8230689
Ketamine is also contraindicated with agonistic-serotonin psychiatric drugs, as it raises blood pressure. In addition, ketamine is also a serotonin reuptake inhibitor, as it has a non-selective effect.
High activity of serotonin receptors does not cause a hypertensive crisis, but extreme fibrillation of the heart.
The entire healthcare system is bad – they learn a lot of impractical nonsense in medicine that they never need in practice, but they understand pharmacology the least. Doctors in Slovakia can stick to incorrectly established treatment procedures for many years throughout their careers, which are contrary to current scientific knowledge. And professional seminars for doctors or Slovak and Czech medical journals are at a very poor professional level.
Hypertension
And perhaps the most significant failure of doctors is the first-choice drug for hypertension. According to the "established model" (this time not only in Slovakia), doctors prescribe several types of drugs that do not affect the heart but work solely on the principle of dehydration, which is very controversial . And dehydration can create predispositions to a whole range of other diseases. Scientific research is not even done on how such drugs affect patients' health in the long term, because if such research were done, very frightening conclusions could be reached.
If I remember correctly, there is already a study proving that one type of these dehydrating drugs causes cancer. Undoubtedly, such drugs shorten life; from a logical point of view , such drugs thicken the blood, thereby increasing the likelihood of embolism, thrombosis, or stroke many times over.
As for hypertension, the first-choice drug should be a beta-blocker (but tolerance to it develops very quickly, which is a disadvantage).
or even better, an imidazoline receptor agonist that works by directly reducing the secretion of adrenaline and similar chemical substances, catecholamines. https://www.ncbi.nlm.nih.gov/pubmed/7533226 (more precisely, they work by reducing the level of catecholamines, which are substances very similar to adrenaline https://en.wikipedia.org/wiki/Catecholamine )
Adrenaline alpha-2 receptor agonist drugs (e.g. clonidine or guanfacine) are also good, which work by reducing the level of noradrenaline in the blood and brain https://en.wikipedia.org/wiki/Alpha-2_adrenergic_receptor
And the best almost miraculous drug is Dipyridamole, which works on the adenosine principle of adenosine receptors https://www.adcc.sk/web/humanne-lieky/ucinna-latka/dipyridamol-6439.html
The heart plays the most important role in blood pressure . Diuretic drugs should be used correctly only for the purpose of possibly eliminating the side effects of beta-blockers, such as edema.
Chemotherapy
By the way, even the most commonly used type of chemotherapy, Paclitaxel, is a very controversial topic. Why do doctors prescribe it when there are much better and gentler types of chemotherapy that don't cause hair loss? And it is ultra-controversial to use the drug Bevacizumab (which is used very often) to treat cancer, which is in complete contradiction to science, because it works on the principle of narrowing and slowing down the growth of blood vessels.
I think there can be several reasons why doctors prescribe drugs that shorten their lives . From ignorance, bad "professional" recommendations from the pharmaceutical lobby, which are contrary to scientific knowledge, to the prescription of a drug by a corrupt doctor in order to get a free holiday from the pharmaceutical company.
But on the other hand, if I say it so cynically, it also has an "advantage": pharmaceutical companies are happy with sick patients when they make more money from them, and it is also good news for the social insurance company when it does not have to pay pensions when people die sooner.